**4. Outcome prediction**

Giving the debatable indication (at least in adults), the high cost and the invasive nature of ECMO treatment and the consequent complications, outcome prediction before treatment initiation is important. In **Table 1**, the outcome predictors of the previously cited publications


are listed and a few other publications [47–49], that have investigated survival predictors for septic shock patients under mechanical support, were added.

**References**

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[2] Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. The New England Journal of Medicine. 2003;**348**:1546-1554

[3] McCune S, Short BL, Miller MK, Lotze A, Anderson KD. Extracorporeal membrane oxygenation therapy in neonates with septic shock. Journal of Pediatric Surgery. 1990;

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[8] Noah MA, Peek GJ, Finney SJ, et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza a (H1N1). JAMA.

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[10] Takauji S, Hayakawa M, Ono K, Makise H. Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: A propensity score analysis in a multicenter retrospective observational study. Acute Medicine & Surgery. 2017;**4**:408-417

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In a Korean case series [47], 28 patients were treated with ECMO, of whom 21 with VA ECMO. The overall survival to discharge rate was 35.7% and predictors of survival appeared to be: a simplified acute physiology score II (SAP II) of 80 or less and pre-ECMO albumin levels.

In another report [48], better outcomes were seen if door-to ECMO times were < 96 h. Furthermore, survival was better in case of Gram-positive infections rather than Gram-negative septic shock. Finally, outcome was better for pneumonia rather than primary bloodstream infections.

The same group [49] also published that the implementation of ECMO during CPR is not beneficial for septic shock patients.
