**3. Conclusion**

In this scenario, PC is still an unmet medical need and new therapies need to be discovered. The ancestral use of natural products in medicine continues in force, but with novel approaches. The increase of chemodiversity together with HTS methods and novel assay models in cancer research make the use of NPs a promising source of novel anticancer drugs. Many more useful natural lead compounds await discovery and the challenge is how to access this natural chemical diversity. More and more multidisciplinary teams are needed to access the world's biodiversity, identify novel compounds and evaluate their potential biological activity.

Promising compounds are currently being tested and many more are expected to be found from diverse natural product sources, with the help of the new trends in cancer research.
