**6. Conclusions**

Pancreatic cancer remains a highly lethal disease. Especially patients with locally advanced pancreatic cancer usually face a discouraging prognosis with limited treatment options. The local ablative therapy with IRE is a valuable additional treatment modality, which, looking at present evidence, seems to have the potential to improve disease-specific and overall survival among patients with this dreadful disease. IRE is technically feasible and generally safe in its open and minimal-invasive access. It can either be applied as in situ IRE in unresectable cases or as a complementary treatment to surgery in borderline resectable patients in order to improve the percentage of true R0 resections. Despite being now an accepted and increasingly applied therapy, there are still a lot of open questions regarding the use of IRE. Future efforts should aim toward the establishment of standard treatment protocols for IRE, in order to make its potential benefit available to more patients suffering from pancreatic adenocarcinoma.
