**6. Experimental and clinical observations on cholesterol metabolism disorder**

ABCA1 and ApoA-I are responsible for the efflux of CH in human monocyte leukemia cell line derived foam cells. This decrease of the concentration of CH can be enhanced by administration of rosiglitazone. (Lü et al., 2010) Animals fed on alternate days have showed lower incidence of lymphomas, after tumor inoculation have had higher survival, and some types of cells have proliferated more slowly. It seems that this diet in humans would favor increased levels of HDL-cholesterol and lower those of triacylglycerol. (Varady et al., 2007) It was found that ether phospholipid edelfosine is able to accumulate and selectively destroy mantle cell lymphoma and CLL cells, underlining the importance of the action on lipid rafts and Fas/CD95 for the therapy of these lymphoproliferations. CH depletion is involved in lipid raft disruption and in the diminishing of drug captation. (Mollinedo et al., 2010)

Some clinical observations on the presence of dyslipidemia in patients with malignant hemopathies are presented in Table 1.


MALT = mucosa-associated lymphoid tissue lymphoma

Table 1. Examples of dyslipidemia in patients with malignant hemopathies.
