**6. Appropriate selection of antiplatelet agents for primary prevention of CVD in type 2 diabetes patients**

Among all choices, there are considerations to be taken into account before types of antiplatelet agents chosen. According to American Diabetes Association (2011), aspirin (75- 162mg/day) should be considered for primary prevention of cardiovascular disease in type 2 diabetes patients for men (>50 years) and women (>60 years) with at least one additional major risk factor (family history of cardiovascular disease, hypertension, smoking, dyslipidemia or albuminuria). The other types of antiplatelet agents either alone or combination with aspirin therapy has no established role in primary prevention of cardiovascular disease in type 2 diabetes patients. In contrast, aspirin should not be recommended for CVD prevention for diabetes patients with low CVD risk (10-year CVD risk <5%, such as in men <50 and women <60 years of age with no additional CVD risk factors, since the potential adverse effects from bleeding likely outweigh the potential benefits (ADA, 2011). A same recommendation goes to type 2 diabetes patients with multiple other risk factors (e.g. 10-year risk 5-10%), in which clinical judgment is required (American Diabetes Association, 2011).
