**HOMA**

8 Dyslipidemia - From Prevention to Treatment

**BMI < 25 BMI 25-29 BMI > 29**

**WAIST < 85 WAIST > 85**

CHOLES LDL HDL TRIG HOMOC HOMA

**Cholesterol LDL HDL Triglycerides Homocysteine**

Fig. 1. Shows the lipid levels in relation to the BMI and the waist of PCOS group.Normal weight and normal waist subjects featured lower LDL and Higher HDL compared to increased waist overweight or obese counterparts. On the other hand, in order to evaluate the influence of metabolic alteration subjects were also stratified on the basis of both HOMA

**(mg/dl) (mg/dl) (mg/dl) (mg/dl) (μmol/L)** 

P < 0,05 LDL WAIST < 85 VS LDL WAIST > 85 P < 0,05 HDL WAIST <85 VS HDL WAIST > 85

and Insulin AUC values (fig.2).

 **(mg/dl) (mg/dl) (mg/dl) (mg/dl) (μmol/L)** 

**BMI (kg\m2)** 

**WAIST (cm)** 

P < 0,05 LDL BMI < 25 VS BMI 25-29 P < 0,05 LDL BMI < 25 VS BMI > 29 P < 0,05 HDL BMI < 25 VS BMI > 29

**I-AUC (UI/ml)** 

 **(mg/dl) (mg/dl) (mg/dl) (mg/dl) (μmol/L)** 

Fig. 2. Shows lipid levels in subjects divided into tertiles for both HOMA and Insulin AUC levels. Similar lipid values were demonstrated in all subjects.

Obesity Related Lipid Profile and Altered Insulin

P < 0,05 P < 0,01 P < 0,001

parameters in all patients.

32-40

Sterility 2000 73, 1261-1262.2.

**2. References** 

Incretion in Adolescent with Policystic Ovary Syndrome 11

**Cholesterol** 

**BMI (kg\m2)** R = 0,1058 R = 0,2252 R = - 0,3930 R = 0,2933

**WAIST (cm)** R = 0,1298 R = 0,2624 R = -0,3756 R = 0,2856

**WHR (cm)** R = 0,2174 R = 0,3039 R = - 0,1924 R = 0,2063

**E2(pmol/L)** R = - 0,0912 R = - 0,0912 R = 0,0541 R = - 0,1495

**A (nmol/L)** R = - 0,0401 R = - 0,0953 R = 0,2933 R = -0,2400

**Tot T (nmol/L)** R = - 0,1848 R = - 0,2191 R = 0,0181 R = 0,0085

**SHBG (nmol/L)** R = - 0,1260 R = -0,1973 R = 0,1038 R = 0,0368

**Fasting Glucose** R = 0,0107 R = 0.0800 R = - 0,1425 R = -0,0092

**Fasting Insulin** R = 0,0773 R = 0,1239 R = - 0,1960 R = 0,0109

**I-AUC 180 min(UI/ml)** R = 0,0324 R = 0,0550 R = - 0,0930 R = 0,0123

**Homocysteine (mol/L)** R = 0,0764 R = 0,0209 R = - 0,0656 R = 0,2863**▪**

Table 5. Linear relationships between lipid assays and phisical endocrine and metabolic

[1] The Rotterdam ESHRE/ASRM sponsored PCOS consensus workshop group. Revised

[2] Hacihanefioglou B. Polycystic ovary syndrome nomenclature: chaos? Fertility and

[3] Ancien P, Quereda F, Matallin P, Villarroya E, Lopez-Fernandez JA, Ancien M, Mauri M,

ovary syndrome (PCOS). Human Reproduction 19: 41,47

2003 consesus on diagnostic criteria and long-term health risks related to polycystic

Alfayate R. Insulin, androgens and obesity in women with and without Policystic ovary syndrome: a heterogeneous group of disorders. Fertility and Sterility 1999 72,

**HOMA** R = 0,1349 R = 0,2269 R = - 0,2800**▪** R = 0,0021

**HDL-**

**Cholesterol Triglycerides** 

**Cholesterol LDL-**


P < 0,05 P < 0,01 P < 0,001

Table 4. Linear relationships between lipid assays and phisical endocrine and metabolic parameters in CONTROLS.


P < 0,05

10 Dyslipidemia - From Prevention to Treatment

**Cholesterol** 

**BMI (kg\m2)** R = 0,0800 R = - 0,0017 R = - 0,4762**▪** R = 0,6962

**WAIST (cm)** R = 0,1410 R = 0,0753 R = - 0,4253**▪** R = 0,6765

**WHR (cm)** R = 0,0326 R = - 0,1535 R = - 0,1878 R = 0,4262

**A (nmol/L)** R = - 0,1921 R = - 0,0280 R = - 0,1845 R = 0,0007

**Tot T (nmol/L)** R = - 0,3425 R = - 0,4544**▪** R = - 0,1377 R = 0,3692

**FSH (IU/L)** R = 0,3094 R = 0,3909**▪** R = 0,3711**▪** R = - 0,1603

**E2(pmol/L)** R = 0,0150 R = 0,0124 R = - 0,0264 R = - 0,0876

**DHEAS (μmol/L)** R = 0,1230 R = 0,1925 R = - 0,1793 R = 0,2206

**SHBG (nmol/L)** R = - 0,2226 R = - 0,2834 R = 0,0655 R = - 0,0942

**17OHP (nmol/L)** R = - 0,0925 R = - 0,0586 R = 0,1667 R = - 0,3703**▪**

**I-AUC 180** 

**Homocysteine** 

parameters in CONTROLS.

P < 0,05 P < 0,01 P < 0,001

**HOMA** R = 0,4724 R = 0,5140 R = 0,2293 R = - 0,0123

**min(UI/ml)** R = - 0,0021 R = 0,0331 R = - 0,3391 R = 0,2882

**(mol/L)** R = 0,2148 R = 0,1214 R = - 0,2604 R = 0,5656**▪**

**Fasting Glucose** R = 0,0440 R = 0,1325 R = - 0,1952 R = - 0,0396

**Fasting Insulin** R = 0,1226 R = 0,1315 R = 0,0435 R = 0,0972

Table 4. Linear relationships between lipid assays and phisical endocrine and metabolic

**HDL-**

**Cholesterol Triglycerides** 

**Cholesterol LDL-**

P < 0,01

P < 0,001

Table 5. Linear relationships between lipid assays and phisical endocrine and metabolic parameters in all patients.
