**3.4 GWAS and LDL-C Levels**

GWAS have confirmed associations between polymorphisms in viable candidate genes including APOB, APOE, LDLR and PCSK9, and have identified novel SNPs associated with LDL-C levels with strong biological plausibility including an inhibitor of lipase (ANGPTL3), see Section 4.1 and a transcription factor activating triglyceride synthesis (MLXIPL) see Section 4.2 (Teslovich et al., 2010).
