**3. Conclusion**

Since OSBP/ORP family involves functional redundancy as well as overlap tissue expression and intracellular localization, the function of each family member has been mostly left unrevealed. Various studies including the genome-wide association study, however, have succeeded to prove the direct association between the individual members and dyslipidemia. Analyses on the individual members have also made it clear that the members affect the regulation of cholesterol and triglyceride level in interaction with diverse molecules.

Nevertheless, the precise molecular mechanism of the process still remains unascertained. The recent findings such as the identification of the small molecule which associates with OSBP are expected to act as a convenient tool to clarify the more detailed functions of OSBP/ORP family in future.
