**2.1 Anti-aging activities**

Previous studies reported the involvement of various clinical parameters in anti-aging actions of fenofibrate (Schlesinger et al., 2009). In particular, chronic, systemic, silent, lowgrade inflammation, named inflammaging is the target for intensive research in aging study (Goto, 2008b). Ross et al. defined arteriosclerosis as "chronic vascular inflammation" resulting from an interaction between oxidized lipid and macrophages (Ross, 1999). Inflammation is involved in the onset of arteriosclerotic disorders and acute coronary syndrome. Furthermore, oxidative stress that can induce a vicious cycle of chronic inflammation has been believed to be the major driving force to promote aging (Yu & Chung, 2001; Romano et al., 2010).

Uric acid has recently been considered to be a prognostic factor for the onset of DM and dementia that may accelerate aging (Hikita et al., 2007; Abate et al., 2004; Martinon et al., 2006), although an excess level of uric acid is the primary incite for gouty attack (Schlesinger et al., 2009).
