**1. Introduction**

262 Dyslipidemia - From Prevention to Treatment

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> Dyslipidaemia is a well-described major independent risk factor for cardiovascular disease (Lin et al.). It is well established that the liver plays the central role in lipid metabolism and liver malfunction is one of the main sources of dyslipidemia (Watson et al., 2003). However, most of the studies so far have focused on the role of hepatocytes in lipid turnover. Indeed, hepatocytes do play a central role in liver lipid metabolism, but they are not alone. Hepatocytes do not have direct contact with the circulation. Any blood-borne lipoprotein particle must first pass through a filter comprised of a layer of endothelial cells, lining the walls of liver sinusoids, before it can contact the liver parenchyma. Likewise, lipoproteins remodelled or synthesized by the liver encounter the same barrier before they reach systemic circulation.
