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**19** 

*Romania* 

Romeo-Gabriel Mihăilă *"Lucian Blaga" University of Sibiu* 

**Cholesterol and Triglycerides Metabolism** 

The aim of this chapter is to achieve a synthesis of the major studies existing in the literature on correlations between lipid metabolism and malignant hemopathies. We will expose the fundamental research data and their impact on clinical treatment. The purpose of this review is to help the clinicians to understand better the pathological disorders of the lipid metabolism and use the existing therapeutic arsenal to improve the treatment outcomes. The research and the recognition of the presence of dyslipidemia is useful, as well as monitoring them during oncological therapy. The treatment of dyslipidemia may not be only an option when a patient with malignant hemopathy has acquired multidrug resistance. It can contribute to reversing this resistance, but it can also have adverse effects that must be

There are numerous studies in literature, but the connection between blood levels of various lipid fractions and hematologic malignancies is still unknown (Cvetkovic et al., 2009). Various epidemiological studies have found that between blood lipids and various neoplastic diseases there are correlations, thus the question is whether in the pathogenesis of cancer are not involved various lipid disorders (Moschovi M et al., 2004). At the same time it is believed that in patients with metabolic syndrome (MS), blood lipid levels may have

Cvetkovic & al. studied 47 patients with malignant non-Hodgkin's lymphoma (NHL) and found that before the treatment, compared with patients in the control group, blood levels of phospholipids, cholesterol (CH) and high density lipoprotein-cholesterol (HDL-cholesterol) had significantly lower values. After chemotherapy (3 or 6 cycles) the blood lipid levels reached even lower values in patients where the disease progressed, as opposed to those who achieved complete remission or whose disease was stationary, cases in which lipids

In an other study conducted in Poland on the lipid levels of 238 patients with different hematological malignant diseases Kuliszkiewicz-Janus M et al. found that HDL-cholesterol values were significantly different from those of patients in the control group when the disease was in active phase, but in the remission phase the difference was statistically significant only in patients with NHL and acute leukemia (Kuliszkiewicz-Janus et al., 2008).

**1. Introduction** 

recognized, followed and treated.

correlations with the risk of cancer (Ulmer H et al., 2009).

increased progressively. (Cvetkovic et al., 2009).

**2. The lipid profile evolution under cancer treatment** 

**Disorder in Malignant Hemopathies** 

