**3. GP and CsA**

Both CsA and Tac are CNI. The GP that closely related to Tac as mentioned above could have more or less the effect on CsA, and as it should be, the effect is not exactly the same. In recent years, Tac gradually replaces the use of CsA, and here we will not make an in-depth introduction.

Reportedly, the influence of the CYP3A5\*3 and CYP3A4\*22 variants on the PK [19, 42, 50, 76–80] or PD [33, 81–84] of CsA are controversial. The effect of CYP3A5\*3 on the CsA PK appears to be weaker than observed for TAC, while the CYP3A4\*22 allele appears to be stronger, which would decrease the clearance of CsA by 15%. As stated in [47], for the time being, no precise dose adjustment has been proposed based on these variants.
