**Meet the editor**

Dr. Khalid Ahmed Al-Anazi is a consultant hemato-oncologist and the Chairman of the Department of Adult Hematology and Hematopoietic Stem Cell Transplantation (HSCT) at King Fahad Specialist Hospital (KFSH) in Dammam, Saudi Arabia.

He graduated from the College of Medicine, King Saud University (KSU) in Riyadh, in 1986. After passing his

Boards in Internal Medicine, he trained in clinical hematology and HSCT at King's College Hospital, University of London, UK. He has 4 years of experience in internal medicine and 26 years of experience in adult clinical hematology and HSCT at Riyadh Armed Forces Hospital, then King Faisal Specialist Hospital and Research Centre (KFSH&RC) in Riyadh, King Khalid University Hospital and College of Medicine, KSU in Riyadh, and KFSH in Dammam, Saudi Arabia.

He received the award of best teacher in the Department of Medicine at the College of Medicine and KKUH in Riyadh in 2014. During his work at KFSH&RC in Riyadh and KFSH in Dammam, he was heavily involved in hemato-oncology and HSCT and he contributed to the success and achievements at both institutions in addition to the establishment of the adult HSCT program at KFSH in Dammam in 2010. He has 85 publications, including retrospective studies, review articles, book chapters, and electronic books, and he is a reviewer for 23 international medical journals. He is the Editor-in-Chief of the *Journal of Stem Cell Biology and Transplantation* and the *Journal of Molecular Genetics and Medicine* in addition to being an associate editor of 26 other medical journals in HSCT, hematology, cancer, and infectious diseases.

Contents

**Preface VII**

**Therapeutics 3** Khalid Ahmed Al-Anazi

**of Myeloma 37**

Sportelli and Angelo Vacca

Khalid Ahmed Al-Anazi

**Section 3 Clinical Aspects of Multiple Myeloma 125**

**in the Era of Novel Therapies 127**

Chapter 2 **Epidemiology of Multiple Myeloma 13**

Chan and María-José Sánchez Pérez

**Section 1 Introduction and Epidemiology of Multiple Myeloma 1**

**Section 2 Pathogenesis, Genetics and Resistance Mechanisms 35**

Chapter 3 **Therapeutic Targets and Signaling Pathways for Diagnosis**

Chapter 4 **Resistance Mechanisms to Novel Therapies in Myeloma 67** Craig T. Wallington-Beddoe and Douglas W. Coghlan

Chapter 5 **Angiogenesis and Antiangiogenesis in Multiple Myeloma 97** Roberto Ria, Antonio Solimando, Assunta Melaccio, Azzurra

Chapter 6 **Hematopoietic Stem Cell Transplantation in Multiple Myeloma**

Tariq Moatter and Afshan Asghar Rasheed

Chapter 1 **Introductory Chapter: Multiple Myeloma in the Era of Novel**

Rafael Ríos-Tamayo, Dolores Sánchez Rodríguez, Yoe-Ling Chang-

Zeeshan Ansar Ahmed, Ashgar Nasir, Muhammad Shariq Shaikh,
