**3.3. EBV viremia and EBV detection by EBER**

The majority of EBV infections that occur after transplantation, especially in adults, are clinically silent reactivations. This leads to a subsequent delay in the diagnosis of PTLD. A positive correlation between the degree of EBV DNAemia and the development of PTLD has significant implications for the importance of monitoring viral load after transplantation. In a study done by Holman et al., the risk of PTLD in viremic patients significantly increased with the peak quantity of EBV DNAemia [2, 13]. Since the occurrence of PTLD is significantly related to the viral load, constant monitoring and quantification of EBV-DNA load are utilized as prognostic markers for the development of PTLD.. In solid organ transplant (SOT) recipients, approximately 50% of patients develop detectable EBV DNAemia, but only a much smaller subset develops PTLD.
