**3. Experimental models used to study the effect of brain death on liver graft quality**

Future research in experimental models of LT using BD donors is required to understand the pathophysiology of BD and elucidate the consequences of BD on graft function and survival [6]. The knowledge of the underlying mechanisms on the detrimental effects of BD is a critical question to promote better preservation of the organ and to improve outcome after LT [1]. A wide variety of BD models have been described in the literature, and in most of them an increase in intracranial pressure is generated by an expanding intracranial balloon, finally leading to BD [26]. This section will discuss about experimental animal models used to evaluate the effects of BD on optimal and steatotic liver grafts.
