**11. Conclusion**

Pancreas transplantation is the best treatment alternative for patients with end-stage renal disease and type 1 diabetes and may be found in the selected group of type 2 diabetic patients. Patient and graft survival have greatly increased in the last decades, particularly due to improvements in surgical procedures and immunosuppression protocols, with graft half-life of 15 years. Following transplantation, patients should be carefully monitored due to the risk of acute rejection, disease relapse, or diabetic secondary complications present prior to the transplant.
