**3.4. EBV antigens**

The broad EBV latency profile (LMP1+/EBNA 2+) is found to be expressed in 59% of EBV (+) PT-DLBCL and is associated with a more elaborated inflammatory response than intermediate latency (LMP1+/EBNA 2-) with a role for innate and tolerogenic immune response in EBV + PT-DLBCL. EBV signature is the most important factor in the pathogenesis of EBV (+) PT-DLBCL [14].
