**Author details**

In 2013, Hervouet et al. found that using SUVIMAX-like diet (supplementation en vitamins et minéraux antioxydants), which was enriched with beta carotene, alpha tocopherol, vitamin C, zinc, and sodium selenite, was delayed the clinical signs on ethyl-nitrosourea induced glioma rat model, but gliomagenesis occurred. This diet just decreased the tumor

In 2017, prolonged survival time was showed treatment with coptis chinensis on glioma

Combination of berbamine and paxitaxel was delayed the development of tumor U87 xeno-

In 1990, Philipov et al. carried out a limited clinical study with 15 patients with malignant brain tumors. There was no significant survival prolongation with selenium addition on

In 1996, Lissoni et al. evaluated the effects of melatonin using with radiotherapy on 30 patients with glioblastoma multiforme. They showed that the melatonin addition in normal therapy provided prolonged survival time, decreased side-effects. Based on these results they sug-

In 2010, Delorenze et al. exhibited that the relationship between daily intake of antioxidants and survival rate was variable depends on tumor grade. They also showed that the supplementation of higher dose vitamin E has increased the survival in grade III gliomas; otherwise,

In 2010, the side-effects welding from radiotherapy were decreased with lycopene supple-

In 2015, Mulpur et al. carried out a study to check complementary therapy options among glioblastoma multiforme patients. They found that multivitamins or omega-3-fatty acids did

Cancer is a personal disease, for this reason, it needs special attention. The above-mentioned evidences have shown that antioxidant supplementation cannot safe at times. Researchers advocate two different opinions regarding using antioxidant in course of cancer treatment. The first opinion is traditional approach. It says antioxidants prevent the normal cell from oxidative damage and they induce toxicity and provide better survival rates. The second one shows the dark side of antioxidants. According to the second opinion: antioxidants are decreased the survival rates by triggering drug-resistance. When we consider these two opin-

The most urgent thing is clinical trials with larger sample size and long-term following. Evidence obtained from in vitro or in vivo studies cannot representative for the 3D organism. The effects

not affect survival, but for Vitamin D and E further investigations are necessity [55].

gested that concomitant therapy may be more effective for glioblastoma patients [27].

vitamin C and genistein were decreased the survival rate [26].

ions we can easily understand the requirement of this area.

mentation in patients with high-grade glioma [54].

aggressiveness [52].

graft model [47].

*4.1.3. Clinical trials*

patients' diet [28].

**5. Conclusions**

induced mice model by Li et al. [53].

238 Glioma - Contemporary Diagnostic and Therapeutic Approaches

Duygu Harmanci

Address all correspondence to: duyguharmanci@gmail.com

Department of Molecular Medicine, Graduate School of Health Sciences, Dokuz Eylul University, Izmir, Turkey
