*2.2.1.2. Adjuvant treatment*

Knowing that the wild-type astrocytomas have a worse prognosis, a low-dose radiotherapy regimen in the immediate postoperative period is recommended instead of close clinical imagistic observation. There are arguments in favor of radiotherapy in terms of prolonged PFS but not necessarily the OS [59]. Due to the fact that the patients receiving associated radiotherapy and chemotherapy have an improved long-term survival [60], a combined radio-chemotherapy regimen seems to be recommendable. Further studies will have to determine whether temozolomide, which was historically preferred by neuro-oncologists due to its lower toxicity and oral administration, is superior or not to PCV [61].
