**3.8. Statistical analysis**

Statistical analysis was performed using GraphPadPrism v7 (Graphpad.com, USA). To identify significant differences of endpoint analyzes, an unpaired two-tailed t-test was used. P-values are given in the respective graphs (column with the treatment). In case of kinetics, two-way ANOVA followed by Sidak's correction for multiple comparison. Multiplicity adjusted p-values are given. Observations with p < 0.05 were considered as significant.
