**Foreword 1**

Chapter 7 **Neurosurgical Options for Glioma 149**

Alireza M. Mohammadi

**Friend or Foe? 231** Duygu Harmanci

Hugo Cerecetto and Marcos Couto

Chapter 11 **Antioxidant Supplementation during Glioma Therapy:**

Suljić

**VI** Contents

Ibrahim Omerhodžić, Almir Džurlić, Adi Ahmetspahić, Bekir

Chapter 8 **Concurrent Thermochemoradiotherapy in Glioblastoma**

Chapter 9 **Laser Interstitial Thermal Therapy in Glioblastoma 187**

Chapter 10 **Medicinal Chemistry of Boron-Bearing Compounds for BNCT-**

**Treatment: Preliminary Results 165**

Rovčanin, Mirela Kalamujić, Nurija Bilalović, Bilal Imširović and Enra

Anastasiya I. Ryabova, Valery A. Novikov, Olga V. Gribova, Evgeny L. Choynzonov, Zhanna A. Startseva, Evgeny G. Grigoryev, Irina A. Miloichikova, Nataliya D. Turgunova and Polina V. Surkova

Daria Krivosheya, Hamid Borghei-Razavi, Gene H. Barnett and

**Glioma Treatment: Current Challenges and Perspectives 205**

It is a tremendous honor for me to have been asked to write an introduction to this book. For a world-class neurosurgeon such as Dr. Omerhodzic, for whom I have tremendous respect, to bestow such an honor upon me is a pleasure.

It was in 1932 that Harvey Cushing wrote: "In these days when science is clearly in the saddle and when our knowledge of disease is advancing at a breathless pace, we are apt to forget that not all can ride and that he also serves who waits and who applies what the horseman discovers…"

Such words are truer today than at any other time in history. It is a credit to Dr. Omerhodzic's sagacity, recognizing that printed books are out of date by the time they hit the bookshelves, that he chose an online format for this compendium such that its information could be updated and disseminated more expeditiously. With that in mind, this book offers the reader the most up-to-date knowledge available on cutting-edge research into novel treatments for patients with gliomas.

But let me be clear, this book is not an entry-level epistle. It contains chapters from cutting-edge glioma research laboratories worldwide—from Boston to Europe, India, China, Mexico City, and beyond. The book covers everything from the extent of surgical resection to molecular genetics and new therapeutic modalities such as laser interstitial thermal therapy, boron neutron capture, and targeting of molecular pathways. This is a book for the serious student with an interest in malignant gliomas. Dr. Omerhodzic has pulled together thought leaders from all continents to offer their most up-to-date research on this deadly disease. I hope you will read with interest.

> *Frederick A. Boop, MD* Professor and J. T. Robertson Chairman Department of Neurosurgery St Jude Children's Research Hospital University of Tennessee Health Science Center, Memphis, TN, USA
