**2.2. Mitogenomic gene coverage by swinger RNAs**

Locations of detected swinger RNAs were recorded by mapping these RNAs on the human mitogenome. We analyse separately 17 mitogenomic regions: the D-loop, 2 ribosomal RNAs (12S and 16S), 13 protein-coding genes involved in the electron transport chain and the WANCY region (intragenic region between ND2 and CO1 that templates for tRNAs with cognate amino acids W, A, N, C and Y). Percentage coverages by detected swinger RNAs were calculated for each swinger transformation in each selected mitogenomic region and used for further statistical analyses.
