**5. Apoptosis alteration**

Apoptotic cell pathway is a defense mechanism for neurons. Alteration of this systeminduced neuronal loss in developing brain affects normal function of neuronal cells, leading to neurodegeneration.

DNA damage is also a common feature of apoptotic pathway, but when this pathway is altered, neuronal defect occurs and, as a consequence, neurodegenerative cell profile D'amelio et al, 2011.
