Preface

This Edited Volume is a collection of reviewed and relevant research chapters, concerning the developments within the neurodegeneration field of study. The book includes scholarly contributions by various authors and edited by a group of experts pertinent to neurodegen‐ eration. Each contribution comes as a separate chapter complete in itself but directly related to the book's topics and objectives.

The book is divided in 5 chapters: 1. Introductory Chapter: A Common Feature of Neurode‐ generative Disorders, 2. Neuroprotective Strategies of Blood-Brain Barrier Penetrant "For‐ skolin" (AC/cAMP/PKA/CREB Activator) to Ameliorate Mitochondrial Dysfunctioning in Neurotoxic Experimental Model of Autism, 3. From Neuronal Differentiation of iPSCs to 3D Neural Organoids: Modeling of Neurodegenerative Diseases, 4. Molecular Basis of Neuro‐ degeneration: Lessons from Alzheimer's and Parkinson's Diseases and 5. Neurodegenera‐ tive Diseases Associated with Mutations in SLC25A46.

The target audience comprises scholars and specialists in the field.

**Antonella Borreca** Umberto Veronesi Post Doc Fellowship at Humanitas Research Hospital Rome, Italy

**Chapter 1**

**Provisional chapter**

**Introductory Chapter: A Common Feature of**

**Introductory Chapter: A Common Feature of** 

DOI: 10.5772/intechopen.84132

The neurodegeneration is a common feature of different disorders, and many partners are involved in this mechanism. The last effect of degeneration is normally observed in the spine defects: reduction of spine density and alteration of morphology or functionality. The degen-

The most neurodegenerative disorders are essentially affected by neurodegeneration of spine density and functionality, but the initial step or the trigger point is different from each other. Neurodevelopmental disorders or neurodegenerative disease related to the age affects patients in different ways but with the same effect. For this reason, a neurodegeneration is normally an intriguing topic for all scientific communities. Some of the molecular pathways involved in neurodegeneration associated to the most common neurodegenerative disorders

The aggregation of protein is normally considered a common feature of neurodegeneration. This accumulation leads to neurotoxicity and neuronal death. The causes of protein accumulation are different, but normally most of them are essentially due to mutation of regulation regions of gene (5'UTR, 3'UTR, etc.). Epigenetic mechanism occurs in regulation of protein synthesis, and accumulation of aggregated protein is a consequence Mus L et al., 2019;

eration of neuron activity normally leads to the complete cell death.

© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use,

distribution, and reproduction in any medium, provided the original work is properly cited.

**Neurodegenerative Disorders**

**Neurodegenerative Disorders**

Additional information is available at the end of the chapter

Antonella BorrecaAdditional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.84132

Antonella Borreca

**1. Introduction**

are listed below.

**2. Accumulation of protein**

Sorrentino za et al 2019; Joppe K et al., 2019.

#### **Chapter 1 Provisional chapter**

#### **Introductory Chapter: A Common Feature of Neurodegenerative Disorders Introductory Chapter: A Common Feature of Neurodegenerative Disorders**

DOI: 10.5772/intechopen.84132
