**9. Probably microglia and inflammation**

Activation of inflammatory pathway generates a neuronal cascade molecule activation following the external stimuli. The inflammatory pathway is also responsible of synaptic pruning with the elimination of immature and nonactive spines. When this system is altered, many of neuronal activities are affected and neurodegeneration occurs.

The study of different molecular pathways of synaptic plasticity is one of the most intriguing mechanism to identify how neuronal works and intervene in neurodegenerative cases. Most of the neuronal diseases are linked to the neurodegeneration. For this reason, the study of this mechanism is essentially important in the field of neuroscience and is necessary to intervene in case of pathology Paasila pj et al., 2019.
