**2. Accumulation of protein**

The aggregation of protein is normally considered a common feature of neurodegeneration. This accumulation leads to neurotoxicity and neuronal death. The causes of protein accumulation are different, but normally most of them are essentially due to mutation of regulation regions of gene (5'UTR, 3'UTR, etc.). Epigenetic mechanism occurs in regulation of protein synthesis, and accumulation of aggregated protein is a consequence Mus L et al., 2019; Sorrentino za et al 2019; Joppe K et al., 2019.

© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
