Contents

### **Preface XI**



Preface

portance of insurance in diabetes mellitus.

various chapters of the book.

Insulin is one of the most important treatment modalities of any diabetologist. Insulin treat‐ ment has undergone a vast change in the last 50 years. From its discovery on the morning of 14 November 1921 and the first injection on 23 January 1922 to Canadian 14-year-old Leo‐ nard Thompson, it has become the mainstay for the treatment for diabetes mellitus. Various reports on medical/laboratory fallacy/misconception have increased the necessity to aug‐ ment insulin safety and resourcefulness. Prominence has relocated from simply diagnosing and treating diabetes to identifying and controlling the disease and risk factors, and main‐ taining health, for which insulin plays a vital role. This book stresses prominence on five facets: defective insulin exocytosis of diabetic cells; insulin resistance; translocation to the muscle membrane; decreased hepatic clearance of insulin; and obesity related to insulin re‐ sistance. In addition to this, the book also focuses on the treatment, immunisation and im‐

This work would not have been possible without the support of IntechOpen. I am especially indebted to Mr Julian Virag, Author Service Manager, IntechOpen, who has been supportive of my book and who worked actively to provide me with all facilities. I am grateful to all those with whom I have had the pleasure to work during this project. Each of the authors of the different chapters has provided me with extensive professional help and obliged me on this scientific venture wherever possible. I would especially like to thank the authors of the

Nobody has been more important to me in the pursuit of this project than the members of my family. I would like to thank my parents, the late Taufiquz Zaman and the late Jaiba Zaman, whose love and guidance are with me in whatever I pursue. Also, I am thankful to my father-in-law, the late Misbahul Hussain, and my mother-in-law, Suraiya Hussain. Most importantly, I wish to thank my loving and supportive wife, Jarin Tanwir Hussain, who is my ultimate role model, and my two wonderful children, Naushad Muntasir Zaman and Umar Sarwar Zaman, who provided me with unending inspiration during the project.

MBBS, MD (Doctor of Medicine in Biochemistry), FID (Fellowship in Diabetes)

**Dr Gaffar S. Zaman**

King Khalid University Kingdom of Saudi Arabia

FIAN (Fellowship in Applied Nutrition)

College of Applied Medical Science

PGDCR (Post Graduate Diploma in Clinical Research)

Assistant Professor, Department of Clinical Laboratory Sciences
