**4.2. Interleukin-6 in metabolic syndrome**

Studies confirmed that IL-6 is correlated with all five of MetS components. The main explanation relies on the fact that the dysfunctional adipose tissue induces macrophagic proliferation with increased IL-6 production [58]. Weiss et al. have found that IL-6 is associated with hypertriglyceridemia, fasting plasma glucose, and hypertension [59]. The same results are confirmed by Sarbijani et al. [17]. They also reported that increasing levels of IL-6 are correlated with MetS severity [17, 59]. Also, Chedraui et al. found increased levels of IL-6 in women with abdominal obesity, lower levels of HDL-C, and hypertriglyceridemia [18]. Another study demonstrated that high IL-6 levels within hepatocytes in a state of chronic inflammation could be a determining cause of MetS development [60].
