**8. Human insulin**

Soluble human insulin (e.g., regular insulin) has a slower absorption profile than the rapidacting analogs (lispro, aspart, and glulisine). The PK and PD of regular insulin, as well as those of neutral protamine Hagedorn (NPH), are highly dependent on the body site injected and the technique used. FITTER recommendations state that:

• IM injections of NPH and long-acting insulin analogs must be strictly avoided due to the risk of hypoglycemia [17, 39–41]. **A2**

