8. Conclusion

Evidence-based medicine continues to evolve into a practical way of integrating feedback from process outcomes and research results into clinical practice, assisting practitioners globally in providing optimal care for their patients. Understanding the different levels of evidence and the strength of recommendations is an integral component of EBM and helps guide decision making, but must consistently be interpreted in the context of sound clinical judgment and a strong therapeutic relationship with our patients. Champions of patient safety and care quality should be familiar with and comfortable in the application of the above concepts in their everyday practice. In addition, excellent knowledge of established standards for reporting evidence, as well as key methodologies used in the process of guideline implementation, will help guide clinicians toward providing the highest quality, safest possible care to their patients. It is crucial to understand that no single study should be accepted as "fact" nor should any study be disregarded based purely on its LSE. Instead, deliberate efforts should be made to critically analyze recommendations and apply them judiciously, after careful consideration of all available evidence has been made in the context of each specific clinical situation and setting. It is essential that healthcare institutions undergo a cultural transformation to ensure that evidence-based safety practices are introduced, effectively implemented, and allowed to achieve their full potential and intended impact [101].
