**Meet the editor**

Dr. Nilufer Bulut was born in 1967 in Turkey. She received her medical school licence from the Gazi University. She has worked as an assistant doctor at the Diskapı Yıldırım Beyazıt E.R.H from 1992 to 1996. From 1997 to 2007, she worked as a specialist at the same institution. She received her side branch education at the Hacettepe University Medical Oncology Institute from

2007 to 2010. She worked as a medical oncologist at the Bursa Ali Osman Sonmez Oncology Hospital from 2011 until 2013 and in the same position at the Bursa Spesial Medical Park Hospital from 2013 until 2015. She was an associate professor at the Kanuni Sultan Süleyman E.R.H from 2016 to 2018 and currently works as a medical oncologist at the same institute.

Contents

**Preface VII**

**Reflections 3** Nilufer Bulut

**Breast Cancer 9** Josie Todd

**Breast Cancer 47**

**Lymph Nodes 79**

Chapter 1 **Introductory Chapter: Carcinogenesis and Clinical**

**Section 2 Surgical Treatment Options in Breast Cancer 7**

Chapter 2 **Oncoplastic Breast Surgery in the Treatment of**

**Section 3 The Importance of Liquid Biopsy in Cancer Diagnosis 45**

Chapter 3 **The Clinical Relevance of Circulating Tumor Cells in Early**

Chapter 4 **Machine Learning Methods for Breast Cancer Diagnostic 57**

Chapter 5 **Triple-Negative Breast Cancer: Expression of Hypoxia-Inducible**

Hayati Md Pauzi and Nurdashima Abd Shukor

**Section 4 Prognostic Significance of HIF1 Alpha 77**

Malgorzata Banys-Paluchowski, Florian Reinhardt and Tanja Fehm

Shahnorbanun Sahran, Ashwaq Qasem, Khairuddin Omar, Dheeb Albashih, Afzan Adam, Siti Norul Huda Sheikh Abdullah, Azizi Abdullah, Rizuana Iqbal Hussain, Fuad Ismail, Norlia Abdullah, Suria

**Factor 1α in Triple-Negative Breast Cancer with Metastasis to**

Anna Maria Badowska-Kozakiewicz and Michał Piotr Budzik

**Section 1 Introduction 1**
