**4.3.5 Low-molecular-weight heparin**

In contrast to warfarin, LMWHs have a predictable dose response with few interactions. Self-administration is generally well-tolerated and acceptable patient compliance has been documented in several studies. Additionally, there is no need for monitoring (Noble & Finlay, 2005). Dose adjustment may be necessary in the elderly, in particular in those with compromised renal clearance. LMWHs have considered to be the standard-of-care in many medical communities (Geerts et al., 2008).
