**5. Conclusion**

Thus, literature data show that stroke has a peculiar organization in time. Тhe vegetative dysrhythmia and failure in the work of the Central control of biorhythms regulation play a key role in these processes.

The night sleep structure investigation is essential part in patients with stroke and patients with cardiovascular disease risk factors. The CR violation leads to the syndrome of desynchronosis—mismatched dynamics of different indicators of the internal environment. This is a potential basis for the cerebrovascular and cardiovascular pathology.

Therefore, including the restoration of the CR with the chronotherapeutics methods is need for the vascular diseases prevention and treatment. Distribution of daily cases of stroke depends on individual properties of CR hemostasis and cerebral hemodynamics, and the specific of the night sleep structure of the of patients. In this regard, there must be a differentiated approach in the treatment of "day" and "night" strokes. The main aspect of reducing the probability of primary and secondary cardiovascular "accidents" development should be the timely detection of sleep disorders and desynchronosis, as one of the leading risk factors. The use of the personalized chronotherapeutics approaches allows to neutralize the negative impact of desynchronosis.
