**Meet the editors**

Hajime Orita is an associate professor at the Department of Surgery, Juntendo University School of Medicine, Shizuoka Hospital. He specialized in surgery of the esophagus and stomach, laparoscopic surgery of the esophagus and stomach (LADG, LTG), endoscopic diagnosis and therapy (upper gastrointestinal tract), endoscopic surgery of esophagus and stomach (ESD),

and chemotherapy for esophageal and stomach cancer patients. Dr. Orita's research focuses on cancer metabolism, Fatty Acid Synthase (FAS) as a cancer treatment, diagnosis and cancer prevention, cancer metabolism, the relationship between cancer and diabetes, chemoresistance research related to CHFR methylation in esophageal and gastric cancer, new cancer suppressor gene (GASDERMIN), working with the National Institute of Genetics, new prognostic predictors for gastrointestinal stromal tumors (GIST), Pfetin by use of proteomics technology, and working with the National Cancer Center Research Institute.

Dr. Hiroshi Maekawa graduated from Gunma University School of Medicine in 1991. After that he was with Juntendo University School of Medicine, Department of Surgery, from 1991 until 1999 when he switched to Juntendo University, Shizuoka Hospital, Department of Surgery where he still works. He was appointed associate professor, Juntendo University Faculty of Health

Science and Nursing from 2011 and assistant professor at the Department of Coloproctological Surgery, Shizuoka Hospital from 2012. His research interests are in the field of pancreatic surgery and fat metabolism in biliary and pancreatic cancer.

Dr. Gibson is an Associate Professor of Medicine at the Vanderbilt University, Vanderbilt-Ingram Cancer Center, where he is Director of Translational Research for Head and Neck Oncology. After obtaining his MD from Johns Hopkins, he completed an Osler Medical Residency and Medical Oncology Fellowship at Johns Hopkins Hospital while concurrently earning a PhD in

clinical investigation from the Johns Hopkins Bloomberg School of Public Health. He currently leads local and national therapeutic trials for aero-digestive cancers, all with translational laboratory components. The overall goals of his research efforts are to bring novel therapeutics to the treatment of aero-digestive cancers based on rational pre-clinical investigation and in the setting of a focus on patient safety and outcomes.

Contents

**Preface VII**

**Gastric Cancer 3**

**and Perspective 23** Shunsuke Sakuraba

**Section 2 Chemotherapy 59**

**Section 3 GIST 67**

Chapter 5 **Gastric GIST 69**

Byoung Jo Suh

Tamer Saafan

Chapter 1 **Reconstructive Procedures after Total Gastrectomy for**

Nebojsa S. Ignjatovic, Tomislav D. Randjelovic, Miroslav P. Stojanovic, Goran Z. Stanojevic and Miodrag N. Djordjevic

Chapter 2 **Laparoscopic Endoscopic Cooperative Surgery: Current Status**

Chapter 3 **Reconstruction after Laparoscopic Distal Gastrectomy 43**

Satoshi Kanda and Tetsu Fukunaga

Chapter 4 **Adjuvant Chemotherapy of Gastric Cancer 61**

**Section 1 Operation 1**
