**Acknowledgements**

The authors acknowledge the financial supports from the National Natural Science Foundation of China (Grant No. 81572278 and 81272798 to X.Z.), China "863" Plan Project (Grant No. 2014AA020610-1 to X.Z.), the Hunan Provincial Natural Science Foundation of China (Grant No. 14JJ7008 to X.Z.), and the Xiangya Hospital Funds for Talent Introduction (to X.Z.). The scientific contributions of Dr. Dominic M. Desiderio and Fang Peng are also acknowledged.

**Author details**

**References**

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md.0000000000010052

Xianquan Zhan\* and Na Li

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Central South University, Changsha, China

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