**Meet the editors**

Prof. Dr. Yusuf Tutar is a faculty member at the Biochemistry Division, Faculty of Pharmacy, University of Health Sciences (Mekteb-i Tıbbiye-i Şahane), Istanbul, Turkey. He is also the head of Molecular Medicine Program. He obtained his MSc and PhD degrees from the Oregon State University and Texas Tech University, USA, respectively. He pursued his postdoctoral studies

from the Rutgers University Medical School and National Institutes of Health (NIH/NIDDK), USA. His research mainly focuses on biochemistry, biophysics, genetics, and molecular biology with a specialization in the field of prion, drug design, cancer, protein structure-function, protein folding, microRNA, pseudogenes, molecular cancer, proteomics, genomics, and protein expression and characterization by spectroscopic and calorimetric methods.

Dr. Lütfi Tutar is currently an Assistant Professor at the Department of Molecular Biology and Genetics, Faculty of Art and Sciences at Kırşehir Ahi Evran University in Kırşehir, Turkey. His inter-disciplinary research focuses on bioinformatics analysis of high-throughput data, microRNAs, smallRNAs, and Heat Shock Proteins (HSPs) in human diseases and other multicellular organisms.

Contents

**Preface VII**

**Section 1 Apoptosis and Necrosis 1**

**Section 2 Apoptosis Inducers 19**

Chapter 1 **From Apoptosis to Regulated Necrosis: An Evolving Understanding of Acute Kidney Injury 3**

Chapter 2 **Apoptosis-Inducing Effect of Artonin E in Breast Cancer 21** Imaobong Etti, Rasedee Abdullah and Arifah Kadir

> **Mechanism Inducing Apoptosis of Cancer Cells 33** Akinobu Ota, Md Wahiduzzaman and Yoshitaka Hosokawa

**Mitochondria-Associated ER Membrane and Its Functional Link**

Ackuvinas Swakin Annammal Vargheese, Krishnan Sundar and

Chapter 3 **Arsenic-Based Anticancer-Combined Therapy: Novel**

Chapter 4 **The Role of Calcium-activated Potassium Channel in**

**Section 3 Proteasome and Signalling Pathways in Apoptosis 69**

Vázquez-López and Arturo Wilkins-Rodríguez

Chapter 5 **Proteasome Activator 28γ: Impact on Survival Signaling and**

Chapter 6 **Signaling Pathways Targeted by Protozoan Parasites to Inhibit**

Laila Gutiérrez-Kobeh, Jorge Rodríguez González, Rosalino

**to Cell Survival and Death 55**

Thandavarayan Kathiresan

**Apoptosis 71** Ralf Stohwasser

**Apoptosis 95**

Shuo Wang and Cheng Yang
