**5. Clinical implications**

The presence of MetS is associated with an increase in the incidence of pre-AD. The possible underlying mechanisms involved in the association of pre-AD in MetS are still unclear. From this study, we concluded that mitochondrial dysfunction could be an important feature of AD pathogenesis in MetS. In addition, the findings indicate that the intervention which improved brain mitochondrial function led to improved cognitive function. These findings provide information regarding the role of mitochondria in the underlying mechanisms of pre-AD in MetS and offer important insights for future research on interventions that aim to improve the quality of life in MetS patients with AD.
