**Meet the editors**

Prof. Jolanta Dorszewska, DSc, PhD, is a chief at the Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences (PUMS), Poznan, Poland. She graduated from PUMS with a MSc degree in Pharmacy in 1987, a PhD degree in 1996, and a DSc degree in Medical Sciences in 2004. She became a full professor in 2016. Between 1999 and 2000, she worked as a research scientist

at the Institute for Basic Research in Developmental Disabilities, New York, USA. She has authored and coauthored about 100 papers (e.g., *Frontiers in Molecular Neuroscience*, *Oncotarget*, *Current Alzheimer Research*, and *Seizure*) mainly concerning the pathophysiology of Parkinson's and Alzheimer's diseases as well as epilepsy and migraine. She is a coauthor and a coeditor of books on genetic and biochemical factors in neurological diseases. She was also a guest editor of two theme issues in *Current Genomics* (2013 and 2014) and an editorial board member of *Advances in Alzheimer's Disease*, *Austin Alzheimer's and Parkinson's Disease,* and *Current Signal Transduction Therapy* (USA). She is a member of the Commission of Neurochemistry of Neurological Sciences, Polish Academy of Science, and Polish Association of Neuropathologists, as well as the International Association of Neuropathologists.

Prof. Wojciech Kozubski, MD, PhD, is the head and chair at the Department of Neurology, University of Medical Sciences in Poznan, Poland. He graduated from the Medical School, Lodz, Poland, in 1980. From 1980 to 1983, he was a PhD student at the Department of Neurology, Medical School, Lodz. After completing his PhD degree, he became an assistant, an adjunct scientific worker, and an assistant

professor at the same department. He attained his scholarship at the Academic Unit of Neuroscience of Charing Cross and Westminster Medical School, University of London (1987–1988), the Department of Neurology, Sackler School of Medicine, University of Tel-Aviv (1990), and the Department of Neurology, University of Trondheim, Norway (1990–1991). He has authored and coauthored over 290 papers (102 of them are original) concerning mainly the pathophysiology of migraine and related headaches, the pathophysiology of stroke and dementia, and the treatment of headaches and stroke. He is a coauthor and a coeditor of the *Handbook of Clinical Neurology for Neurologists* on brain tumors, affective diseases of the nervous system, and therapy in neurology; an editor of the *Handbook of Treatment in Neurology*; a coauthor and a coeditor of the *Handbook of Clinical Neurology for Medical Students*; and a coauthor of a monograph on stroke aphasia. He was the president of the Polish Neurological Society from 2011 to 2014 and the president of the Polish Headache Society from 1999 to 2001.

Contents

**Preface VII**

**Modulators 1**

and Kamil Kuca

Chapter 1 **Amyloid Beta Hypothesis: Attention to β- and γ-Secretase**

Chapter 3 **Defining Microglial Phenotypes in Alzheimer's Disease 41**

Chapter 4 **Mitochondrial Link Between Metabolic Syndrome and**

Marina Janelidze and Nazibrola Botchorishvili

Chapter 8 **Passive Immunotherapy in Alzheimer's Disease 129**

Chapter 2 **Alzheimer's Disease: Beyond the Neuron 21** Aradhana Verma and Matthew Zabel

Douglas Walker and Lih-Fen Lue

**Pre-Alzheimer's Disease 59**

and Siriporn C. Chattipakorn

Janusz K. Rybakowski

Chapter 6 **Mild Cognitive Impairment 91**

Kevin T. Ong

Chapter 7 **Challenges in Dementia Studies 109**

Philip J. Dolan and Wagner Zago

Chapter 5 **Lithium and Alzheimer's Disease: Experimental, Epidemiological, and Clinical Findings 79**

Jan Korabecny, Katarina Spilovska, Ondrej Soukup, Rafael Dolezal

Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn
