Contents

### **Preface XI**


Chapter 8 **Passive Immunotherapy in Alzheimer's Disease 129** Philip J. Dolan and Wagner Zago

Preface

treat it effectively.

publication.

social and economic problem for many countries.

gression of the disease and delay its occurrence.

The progress of medicine and technology in the second half of the twentieth century has led to an increase in life expectancy. This phenomenon was accompanied by a higher incidence of diseases typical for old age, including Alzheimer's disease. It is known that the incidence of Alzheimer's disease is largely dependent on the patient's age. Alzheimer's disease is cur‐ rently considered an incurable disease with an incomplete etiology and comprises a serious

Nowadays, Alzheimer's disease is considered to be the most common dementia and leads to severe impairment of the patient, and even the final stage of the disease requires constant care of a mentally retarded older person. This book presents contemporary insights into the pathogenesis of Alzheimer's disease and currently used therapies that lead to slow the pro‐

This publication sums up the knowledge of the genetic, biochemical, and immunological fac‐ tors influenced in this dementive disease. It summarizes the pathophysiology observed both in Alzheimer's disease patients and in experimental studies. The book also contains the latest views on the molecular mechanism of dysfunction in this disease and life-long diagnosis. We hope that this book may help in understanding the complex mechanisms of Alzheimer's disease pathogenesis and may be an inspiration to find factors to prevent this disease and to

This book was created, thanks to the authors who wanted to share their scientific achieve‐

The editors would like to acknowledge the authors from various parts of the world and all other people who helped with the production of this book for their participation in this

**Professor Jolanta Dorszewska, MDs, PhD**

Poznan University of Medical Sciences

**Professor Wojciech Kozubski, MD, PhD**

Poznan University of Medical Sciences

Laboratory of Neurobiology Department of Neurology

Department of Neurology

Poland

Poland

ments in the field of basic and clinical research in dementive diseases.
