**Acknowledgements**

For supporting and influencing this long lasting work of T.A.K thanks go to: M. Wachsmuth, T. Weidemann, K. Fejes-Toth, M. Göker, R. Lohner, M. Stör, E. Spiess, K. Rippe, W. Waldeck, C. Cremer, T. Cremer, K. Erenpreisa, A. Ollins, D. Ollins, K. Sullivan, C. C. Murre, J. Skok, A. M. A. Imam, F. G. Grosveld, K. Egger, O. Zimina, and last but not least L. A. Knoch, as well as the German and International Societies for Human Ecology. T2C was invented by T.A.K. and F. G. Grosveld, with many thanks to M. Lesnussa, N. Kepper, A. Abuseiris, P. Kolovos, Jessica Zuin, R. W. W. Brouwer, H. J. G. van de Werken, W. F. J. van IJken, and Kerstin S. Wendt. This work was also part of the EpiGenSys consortium setup and coordinated by T.A.K., funded by ERASysBio+/FP7 and the national funding organizations (the Dutch Ministry for Science and Education, the Netherlands Science Organization, the UK Biotechnology and Biological Sciences Research Council, and the Bundesministerium für Bildung und Forschung (BMBF)). Further support came from the BMBF under grants # 01 KW 9602/2 (Heidelberg 3D Human Genome Study Group, German Human Genome Project), #01AK803A (German MediGRID), #01IG07015G (Services@MediGRID), as well as the Erasmus Medical Centre and the Hogeschool Rotterdam. The High-Performance Computing Center Stuttgart (HLRS; grant HumNuc), the Supercomputing Center Karlsruhe (SCC; grant ChromDyn), and the Computing Facility of the German Cancer Research Center (DKFZ) are thanked for access to their CRAY T3E and IBM SP2s in the initial part of this work. Thanks also go to all those institutions, universities, and companies providing us computational grid resources: the German D-Grid, the European Grid Initiative EGEE, as well as the Erasmus Computing Grid the Almere Grid, and all the unnamed computing grids there is access through via these. Very special thanks go also to all the world-wide distributed and unnamed donors of desktop computer power of our world-wide Correlizer@home BOINC grid!
