**Acknowledgements**

SO Angel (Researcher), L. Vanagas (Researcher), and S.M. Contreras (Fellow) are members of National Research Council of Argentina (CONICET). SO Angel and L. Vanagas are professors of Universidad Nacional General San Martin (UNSAM). This chapter was supported by ANPCyT PICT 2015 1288 (S.O.A.) and National Institute of Health (NIH, NIAID 1R01AI083162) grants.
