**Acknowledgements**

The information in this chapter has been funded wholly (or in part) by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use. Parts of this chapter are reproduced from the authors' previous publications [11, 18–20, 25, 58, 60, 62, 63, 66, 81, 84, 95].
