Contents



Dybushkin, Viktor Fedoseev and Dmitriy Smirnov

Chapter 7 **Ovarian Reserve Markers: An Update 113** Harold Moreno-Ortiz, Iván Darío Acosta, Elkin Lucena-Quevedo, Luis Alejandro Arias-Sosa, Alix Eugenia Dallos-Báez, Maribel Forero-Castro and Clara Esteban-Pérez

Preface

conditions.

heart failure.

microRNA profiling and data analysis.

A biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism. This book discusses biomarkers for various

In Part I, chapters focus on breast cancer—the most common cancer in women accounting for about one third of cancer cases in this population and more than 10% of all cancers worldwide—and pancreatic cancer. Another chapter covers methodological challenges in

In Part II, chapters focus on different biomarkers of non-cancer diagnoses/diseases, includ‐ ing sepsis, childhood renal diseases, pulmonary diseases, Alzheimer's, leishmaniasis, and

The chapter on sepsis addresses the use of blood and serum biomarkers and clinical scores for the diagnosis and prognosis of septic patients. In trauma, fibrin degradation product and D-dimer have been used to predict the likelihood of haemorrhage, whereas in cardiac pul‐ monary arrest, they are used to predict the return of spontaneous circulation. The chapter on clinical application of coagulation biomarkers explains this phenomenon. The chapter on ox‐ idative status pathways discusses the unique property of the human oxidative status. The chapter on ovarian reserve markers talks about anti-Mullerian and follicle-stimulating hor‐ mones. The chapter on childhood renal diseases covers biomarkers of acute and chronic kid‐

Measurement of biomarkers in exhaled breath condensate offers a novel way of monitoring lung inflammation and damage by oxidation stress, and provides insight into the physiolo‐ gy of the disease as mentioned in the chapter on molecular diagnostics of pulmonary diseas‐ es. A chapter on Alzheimer's talks about topological biomarkers hidden in auditory sensory gating network, and a chapter on the neglected tropical disease leishmaniasis, which causes high mortality worldwide, explores the possibility of using biomarkers to develop a rapid

I hope that this book will be of particular interest to researchers, scientists, clinicians, and students from medicine, cancer biology, cell and molecular biology, and other related areas.

**Dr. Ghousia Begum**

Indian Institute of Chemical Technology, India

ney diseases in children, such as urinary tract infection and diabetic nephropathy.

diagnosis kit for universal use. The final chapter is on heart failure and biomarkers.

