**Meet the editor**

Dr. Ghousia Begum has a PhD from Osmania University, Hyderabad, India, where she continued her postdoctoral work. In 1998, she was appointed Junior Scientist in the Biology Division of CSIR-Indian Institute of Chemical Technology (IICT). She has significantly contributed to the fields of Ecotoxicology, Biochemical and Molecular Mechanisms of Toxicity, and Environmental

Biology. Her research interests lie in how environmental changes, particularly toxicants, affect physiological functions in aquatic animals, especially in fish. She is also working on alternative animal models, including lower invertebrates (Daphnia) and vertebrates (zebrafish and edible fishes), for toxicity evaluation. She has published more than 30 research articles in reputed journals and has more than 500 citations to her credit. She was awarded the Young Scientist Award in 1993 and the Scientist of the Year Award in 2012, both by the National Environmental Science Academy (NESA). She was also awarded a gold medal for academic excellence. She is editor of the book Ecotoxicology (2012) as well as editor of two journals. She is editorial board member of 11 journals and has served as a peer reviewer for journals in the areas of environmental biology, toxicology, and related areas.

Contents

**Preface VII**

**Section 1 Biomarkers of Cancer 1**

**Discovery 31**

Chapter 1 **Biomarkers in Breast Cancer 3**

Carla Cedolini and Laura Mariuzzi

and Maria Teresa Di Martino

**Section 2 Biomarkers of Diagnosis-Diseases 55**

**Pancreas Cancer 47**

Di Somma

Chapter 2 **Circulating MicroRNA Profiling in Cancer Biomarker**

Serena Bertozzi, Ambrogio P Londero, Luca Seriau, Roberta Di Vora,

Francesca Scionti, Pierosandro Tagliaferri, Pierfrancesco Tassone

Chapter 3 **Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Mean Platelet Volume for Detection of Resectable**

Chapter 4 **Biomarkers Utility for Sepsis Patients Management 57**

Chapter 5 **Clinical Application of Coagulation Biomarkers 83**

Chapter 6 **Oxidative Status Pathways: Systemic Biomarkers 97**

Dybushkin, Viktor Fedoseev and Dmitriy Smirnov

Makoto Aoki, Shuichi Hagiwara and Kiyohiro Oshima

Kemal Turker Ulutas, Inanc Samil Sarici and Ozgul Duzgun

Agustin Iskandar, Hani Susianti, Muhammad Anshory and Salvatore

Peter Zolotukhin, Viktor Chmykhalo, Anna Belanova, Alexander
