**4. Conclusions**

Oxidative status pathways-based interactomic profiling using the expression analysis-based methods promises a lot to the field of development of the novel diagnostic approaches and has already demonstrated great results in various areas of biomedicine. In this branch of personalized medicine, interactomics serves as a tool to select factors to be analyzed (systemic biomarkers), to suggest a method of analysis and to further account for data collected. Expression profiling then serves as the immediate molecular biological procedure used to collect biological data in the interactomic diagnostics.

Current advances in molecular biology have led to creation of numerous interactomic maps and analytical systems that can readily be used for developing novel diagnostics assays. Fast evolution of oxidative status cell biology and emerging molecular biology suggestions on cellular factors to be considered as systemic biomarkers candidate complement and promote this field. Despite the complexity of development of systemic biomarker-based assays, this novel type of diagnostic technologies appears to be inextricably intertwined with the personalized medicine era.
