**Acknowledgements**

The work was supported from The Ministry of Education, Youth and Sports of the Czech Republic under the NPU I (LQ1604) National Sustainability Program II (Project BIOCEV-FAR) and by the project "BIOCEV" (CZ.1.05/1.1.00/02.0109). European Regional Development Fund-Project "PharmaBrain" (No. CZ. CZ.02.1.01/0.0/0.0/16\_025/0007444), project AZV MZ 17-31852A and by the "Sustainability for the National Institute of Mental Health ( LO1611).
