**3. Discussion and conclusions**

Ovarian reserve (OR) is characterized by the number of eggs cells available to be fertilized throughout the female reproductive lifespan. OR is related with the capacity of female fertility suggesting that the clinical potential of measuring different biomarkers is a perfect tool to predict infertility cases. This has led to research to determine the high predictive value of different biomarkers and to increase treatment factors and to prevent new cases of infertility.

Recent studies have investigated biomarkers such as AMH levels and AFC considered first line tests for counseling patients who desire future fertility due to high predictive value. The relevance of FSH, LH, estradiol, ovarian volume, and inhibin B as biomarkers of OR is considered of low potential for clinical evaluation because predictive superiority of other metrics have emerged with robust studies. Nevertheless, recent studies have constructed algorithms to integrate different biomarkers and approach individualized and reliable evaluations to establish with confidence the risk factors of infertility.
