**2.6. Evaluation of the clay nanoparticles toxicity in epithelial cells**

The extending continuous use of products containing nanoparticle for a wide range of applications has raised public health and safety concerns. Although products containing clay nanoparticles cannot be toxic, human contact during its preparation, production, or disposal process can have undesirable effects on health, which makes it necessary to evaluate the biocompatibility of clay nanoparticles. A group of researchers examined the effects of platelet toxicity (Bentone MA, ME-100, Cloisite Na+, Nanomer PGV, and Delite LVF) on human lung [57]. They used automated cells for the first time in real-time impedance imaging compositions and also showed the effect of toxicity on the difference in the dose level and the timedependent of both types of clay nanoparticles [57]. Clay nanoparticles are used in a wide range of modern products such as electronic, food, clothing, tire, medicine, sunscreen, cosmetics, sports equipment, polymer composites, bone implantation, controlled drug delivery systems, protective coatings (such as anti-corrosion, antibacterial, or antimolding), and for the synthesis of materials [58]. Clay nanoparticles, for example, plastic nanocomposites, are being developed to create unique devices for the next generation of biological applications, including antimicrobial agents, drug delivery, and cancer treatment [59–62].
