**10. Immunosuppressive therapy**

A specific team is taking care of immunosuppressive therapy. It starts with 500 mg iv bolus of solumedrol at the CPB weaning. Once admitted in the ICU, the patient will receive 125 mg bolus of solumedrol every 8 hours, with a specific descending dose scheme.

Antithymocyte globulines (1.5 mg/kg iv) are usually given 4, 24, and 48 hours after the end of the transplantation. They will be adjusted based on eventual presence of high body temperature, bleeding, and thrombocytopenia. There are several possible immunosuppressive agents that will be tailored for the patient such as tacrolimus, cyclosporin A, everolimus, and mycophenolate.
