Preface

Chapter 7 **Mechanical Circulatory Support as Bridge to Pediatric Heart**

Chapter 8 **Orthotopic Heart Transplantation: Bicaval Versus Biatrial**

Sofia Martin-Suarez, Marianna Berardi, Daniela Votano, Antonio Loforte, Giuseppe Marinelli, Luciano Potena and Francesco Grigioni

Massimo Baiocchi, Maria Benedetto, Marta Agulli and Guido

Lucas Barbieri, Noedir Stolf, Mariane Manso and Wallace André

Chapter 11 **Humoral Rejection in Cardiac Transplantation: Management of**

Umit Kervan, Dogan Emre Sert and Nesrin Turan

Chapter 13 **Post-Heart Transplantation Lymphoproliferations 183**

Chapter 14 **Cardiac Re-Transplantation: A Growing Indication with Unique**

Martin Schweiger and Michael Huebler

**Transplantation 93**

**VI** Contents

**Section 4 Intra- and Peri-Operative Issues 107**

**Surgical Technique 109**

Chapter 9 **Heterotopic Heart Transplantation 123**

**Transplantation 133**

**Section 5 Related Adverse Events 157**

Chapter 12 **Graft Vascular Disease 171**

Pedro da Silva

Sylvain Choquet

**Section 6 Re-Replacement Therapy 195**

**Considerations 197**

Robert JH Miller and Kiran Khush

Frascaroli

Hannah Copeland and Jack G. Copeland

**Antibody-Mediated Rejection 159**

Chapter 10 **Anesthesia and Intensive Care Management for Cardiac**

Heart transplantation currently remains the 'gold standard' solution in terms of 'radical' treatment of refractory end-stage heart failure.

In December 2017 we celebrated the 50th anniversary of the world's first human heart trans‐ plant and over time the results have increasingly improved. Historically and currently, ini‐ tial limitations such as 'no proper' definement of brain death, timing for organ procurement with the need of heart electrical activity cessation, absence of 'correct' cold organ storage not allowing long-distance transportation, the need of an adequate immunosuppressive thera‐ py, the requirement of multidisciplinary teamwork, proper recipient and donor selection, and lack of donors to be balanced by reliable technology in terms of both temporary extrac‐ ardiac and long-term implantable mechanical circulatory support therapy are now outdated, thus providing a dramatic expansion of heart transplantation therapy.

Thanks to the contributions of well-known experts in the field, the goal of this book is to provide a framework for a successful transplant program development and management. The text reflects the global collective efforts of those who have dedicated countless energy to achieving a better understanding of the details that will ultimately yield better outcomes in terms of teamwork.

The book is divided into different sections. The chapters focus on historical background and transplant evolution, the current transplant clinical panorama, indications and patient selec‐ tion, both adult and pediatric transplant population issues, intra- and perioperative settings, surgical strategies, and transplant-related adverse events.

This is an additional contribution to the field of heart transplantation, which hopefully will inspire others to further advance this 'milestone' in terms of adequate treatment of endstage heart failure, which will dramatically affect most of our patients.

#### **Dr. Antonio Loforte, MD, PhD**

Cardiothoracic Surgeon Department of Cardiothoracic, Transplantation and Vascular Surgery S. Orsola Hospital, ALMA Mater Studiorum University of Bologna, Italy

#### **Dr. Andrea Montalto, MD**

Cardiothoracic Surgeon Department of Cardiac Surgery and Transplantation S. Camillo Hospital, Rome, Italy

**Dr. Cristiano Amarelli, MD** Cardiothoracic Surgeon Department of Cardiac Surgery and Transplantation Monaldi Hospital, Naples, Italy

**Section 1**

**Introduction**

**Section 1**
