**12. PRRX1 rs3903239 gene polymorphism**

PRRX1 (paired-related HomeBox 1) is a gene encoding homedomain transcription factor that is expressed high in the developing heart. As a result of GWAS, the molecular mechanisms related to AF have been tried to be elucidated. In a recent meta-GWAS, significant correlations were found between the risk of developing rs3903239 polymorphism and AF on the 1q24 chromosome of the PRRX1 gene. In another study conducted with the Greek population, the role of the genetic interaction between PRRX1 rs3903239 and PITX2 rs2200733 gene polymorphisms in the development of AF was investigated and no significant interaction could be detected between these polymorphisms in AF patients. In addition, there was no significant difference in terms of PRRX1 rs3903239 allele frequencies and genotypes between AF patients and healthy controls in the same study. In another study conducted with the Chinese population, PRRX1 rs3903239 gene polymorphism was not detected as a significant genetic risk factor for AF [29].
