**Acknowledgements**

This chapter was performed by Nevra Alkanli, Arzu Ay and Suleyman Serdar Alkanli in department of Biophysics of T.C. Halic University Medical Faculty, Trakya University Medical Faculty and Istanbul University Medical Faculty.

[6] Feng W, Sun L, Qu XF. Association of AGTR1 and ACE2 gene polymorphisms with structural atrial fibrillation in a Chinese Han population. Die Pharmazie. 2017;**72**:17-21.

Gene Polymorphisms Associated with Atrial Fibrillation http://dx.doi.org/10.5772/intechopen.76920 21

[7] Bonilla IM, Sridhar A, Györke S. Nitric oxide synthases and atrial fibrillation. Frontiers in Physiology Cardiac Electrophysiology. 2012;**3**:3-105. DOI: 10.3389/fphys.2012.00105 [8] Moguib O, Raslan HM, Rasheed IA. Endothelial nitric oxide synthase gene (T786C and G894T) polymorphisms in Egyptian patients with type 2 diabetes. Journal of Genetic

Engineering and Biotechnology. 2017;**15**:431-436. DOI: 10.1016/j.jgeb.2017.05.001

[9] Sivria N, Unlu A, Palabiyik O. Endothelial nitric oxide synthase intron 4a/b polymorphism in coronary artery disease in Thrace region of Turkey. Biotechnology & Biotechnological Equipment. 2014;**28**(6):1115-1120. DOI: 10.1080/13102818.2014.980030 [10] Nagai T, Ogimoto A, Okayama H. A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy. Circulation Journal.

[11] Carballo S, Pfenniger A, Carballo D. Differential association of Cx37 and Cx40 genetic variants in atrial fibrillation with and without underlying structural heart disease. International Journal of Molecular Sciences. 2018;**19**:295. DOI: 10.3390/ijms19010295 [12] Piťha J, Hubáček JA, Piťhová P. The connexin 37 (1019C>T) gene polymorphism is associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in

[13] Shuxin H, Yingmin L, Huang D. Association of atrial fibrillation with gene polymorphisms of connexin 40 and angiotensin II receptor type 1 in Chongming adults of shanghai. International Journal of Clinical and Experimental Medicine. 2015;**8**(7):11803-11810

[14] Jiang NX, Xu YH, Xia JW.Impact of GGCX polymorphisms on warfarin dose requirements in atrial fibrillation patients. Turkish Journal of Medical Sciences. 2017;**47**:1239-1246.

[15] Kamali X, Wulasihan M, Yang YC. Association of GGCX gene polymorphism with warfarin dose in atrial fibrillation population in Xinjiang. Lipids in Health and Disease.

[16] Schreieck J, Dostal S, von Beckerath N. C825T polymorphism of the G-protein 3 subunit gene and atrial fibrillation: Association of the TT genotype with a reduced risk for atrial fibrillation. American Heart Journal. 2004;**148**:545-550. DOI: 10.1016/j.ahj.2004.03.024 [17] Chang SH, Chang SN, Hwang JJ. Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. Circulation Journal.

[18] Wang L, Meng X, Yuchi Z. De novo mutation in the SCN5A gene associated with Brugada syndrome. Cellular Physiology and Biochemistry. 2015;**36**:2250-2262. DOI:

women with central obesity. Physiological Research. 2010;**59**:1029-1032

DOI: 10.1691/ph.2017.6752

2007;**71**:1932-1936

DOI: 10.3906/sag-1609-26

2012;**76**:184-188. DOI: 10.1253/circj.CJ-11-0525

2013;**12**:149

10.1159/000430189
