**3. Conclusion**

South African flora characterized by high endemism and unique floral kingdom is only located in the great cape region. Lamiaceae is represented by ~308 species widely distributed all over the country. In general, the bioprospecting of SA flora including Lamiaceae is not reached; yet the required level and more attention are required to explore the potential of their chemical constituents. The present work shades the light on the isolated terpenoids of all listed species in updated SA flora checklist. It is interesting to indicate that *Plectranthus* genus contains mostly abietane diterpenes and shows potent activity as demonstrated by coleon U and parviflorons F and D. On the other hand, leoleorin C from *L. Leonurus* showed moderate binding affinity (*Ki* = 2.9 μM) to the Sigma 1 receptor. These compounds and others may be considered as a model for drug discovery for human benefits.
