**2.17.** *Vitex* **genus**

*Vitex* genus is represented by 12 species in SA. The fraction responsible for antimicrobial activity of *V. rehmannii* was purified to give a labdane diterpene as an inseparable epimeric mixture of 12*S*,16*S*/*R*-dihydroxy-*ent*-labda-7,13-dien-15,16-olide (**222**). The extract and the labdane diterpene exhibited good antimalarial activity, with the labdane diterpene being the most active IC50: 2.39 ± 0.64 μg/mL [106].
