Author details

Chunxiu Liu<sup>1</sup> \*, Chenghua Xu1 , Ning Xue1 , Jian Hai Sun<sup>1</sup> , Haoyuan Cai<sup>1</sup> , Tong Li<sup>1</sup> , Yuanyuan Liu<sup>2</sup> and Jun Wang<sup>3</sup>

\*Address all correspondence to: cxliu@mail.ie.ac.cn

1 State Key Laboratory of Tranducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing, China

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Author details

\*, Chenghua Xu1

\*Address all correspondence to: cxliu@mail.ie.ac.cn

UK: Oxford University Press; 1987. pp. 86-92

Journal of Clinical Pathology. 1995;104:S111-S127

Trends in Analytical Chemistry. 2011;30:887-898

glucose. Analytical Chemistry. 1984;56:667-671

conjugated polymers. Sensors. 2008;8:118-141

Science and Engineering: C. 2013;33:1853-1859

Yuanyuan Liu<sup>2</sup> and Jun Wang<sup>3</sup>

66 MEMS Sensors - Design and Application

Sciences, Beijing, China

, Ning Xue1

2 Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China

, Jian Hai Sun<sup>1</sup>

1 State Key Laboratory of Tranducer Technology, Institute of Electronics, Chinese Academy of

3 School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China

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, Tong Li<sup>1</sup>

,

Chunxiu Liu<sup>1</sup>

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**Chapter 4**

**Provisional chapter**

**Micropatterning in BioMEMS for Separation of Cells/**

Biofluids remain a difficult issue in some drug delivery processes for separation of bioparticles through microchannels. This chapter reviews the techniques which have been substantiated and proven helpful for the separation of particles depending on mass and size with some constraints of high throughput. In this study, a key focus will be on separation criterion by patterning of a microchannel and utilize sieve type channels based on spherical bioparticles. The first part focuses on the designing of the pattern for issues of the network like clogging and theoretical experiments by both hydrodynamic and other passive methods for sorting/separation. The second part focuses on the simulations for separation for small and larger bio particles depending on mass and size, samples of blood and other Klebsiella infected fluidic samples for the experiment. The theme provided for mass and size-based separation is simple and can accomplish operations in microfluidics for

several biological experiments, diagnosis approaches and zoological researches.

**Keywords:** microfluidics particle sorting, patterning, Klebsiella and other bioparticle,

A portion of MEMS, that is, micro electro mechanical system technology has contributed in various applications of sensors and actuators, BioMEMS applications [1] in which it has played a crucial role for Micro/Nano fluidic devices and a key role for validating a factor in integration of multiple functions for different microdevice and miniaturization. These technologies of Microsystem are used widely in biomedical, disposability, low power consumption, low cost as well as it incorporates multiple phenomena physically and due to its design

complications it is difficult to deploy these devices than other sensors [1].

**Micropatterning in BioMEMS for Separation of Cells/**

© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use,

distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: 10.5772/intechopen.76060

Rajagopal Kumar and Fenil Chetankumar Panwala

Rajagopal Kumar and Fenil Chetankumar Panwala

Additional information is available at the end of the chapter

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.76060

COMSOL Multiphysics 5.2a

**Bioparticles**

**Abstract**

**1. Introduction**

**Bioparticles**


#### **Micropatterning in BioMEMS for Separation of Cells/ Bioparticles Micropatterning in BioMEMS for Separation of Cells/ Bioparticles**

DOI: 10.5772/intechopen.76060

Rajagopal Kumar and Fenil Chetankumar Panwala Rajagopal Kumar and Fenil Chetankumar Panwala

Additional information is available at the end of the chapter Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.76060

#### **Abstract**

[57] Vaddiraju S, Tomazos I, Burgess DJ, Jain FC, Papadimitrakopoulos F. Emerging synergy between nanotechnology and implantable biosensors: A review. Biosensors & Bioelectronics.

[58] Crespi F. Wireless in vivo voltammetric measurements of neurotransmitters in freely

[60] http://www.medgadget.com/2014/09/abbott-freestyle-libre-flash-continuous-glucose-moni

behaving rats. Biosensors & Bioelectronics. 2010;25(11):2425-2430 [59] http://www.medtronicdiabetes.com.cn/. [Accessed: November 20, 2017]

toring-system.html. [Accessed: May 20, 2014]

[61] http://www.senseonics.com. [Accessed November 30, 2017]

2010;25(7):1553-1565

70 MEMS Sensors - Design and Application

Biofluids remain a difficult issue in some drug delivery processes for separation of bioparticles through microchannels. This chapter reviews the techniques which have been substantiated and proven helpful for the separation of particles depending on mass and size with some constraints of high throughput. In this study, a key focus will be on separation criterion by patterning of a microchannel and utilize sieve type channels based on spherical bioparticles. The first part focuses on the designing of the pattern for issues of the network like clogging and theoretical experiments by both hydrodynamic and other passive methods for sorting/separation. The second part focuses on the simulations for separation for small and larger bio particles depending on mass and size, samples of blood and other Klebsiella infected fluidic samples for the experiment. The theme provided for mass and size-based separation is simple and can accomplish operations in microfluidics for several biological experiments, diagnosis approaches and zoological researches.

**Keywords:** microfluidics particle sorting, patterning, Klebsiella and other bioparticle, COMSOL Multiphysics 5.2a
