**2. DNA gene spray microfluidic chip technology**

Biomedical wafers have many advantages such as trace detection, accurate quantification, automatic operation and rapid parallel processing. Compared with traditional biomedical testing, biomedicine wafers have great advantages and so far, many breakthroughs have been made Technological development. But it cannot be denied that biomedical chips are also facing many technical challenges that need to be overcome by scientists in different fields.

As the design and manufacture of biomedical wafers are cross-cutting projects that involve the operation of microfluidic systems, biomedical reactions and optical signal detection, they are quite different from the highly specialized professional division of labor in many traditional engineering fields. In addition to professional requirements, biomedical wafer design and manufacturing, attaches great importance to cross-cutting technology and communication skills.

accurate or not. The way in which the foamed beads are produced will produce a series of beaded beads, that is, in addition to the main beaded beads, Subsequent satellite beads have a considerable degree of impact on accurate quantitation. The program has a complete set of main bead, quantitative determination of liquid beads, in line with biomedical specimens of liquid bead quantitative requirements, this study used to create disease detection and DNA

Precisely Addressed (DNA Gene) Spray Microfluidic Chip Technology

http://dx.doi.org/10.5772/intechopen.74611

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DNA micro-array, bio-chip or DNA chip combination of molecular, materials, motors and other fields of products. This system can be divided into DNA chip, protein chip, cell chip, tissue chip. However, only the first two are commonly used, in which a DNA chip can detect changes in the concentration of mRNA in a cell. The biggest advantage of gene microarrays is the ability to quickly and accurately provide a large number of genetic tests and to understand the performance of these genes. This is a considerable help in understanding the transmission of genes.

The main body of the chip is the use of glass, nylon, silicone, ceramic and other materials. Above there are probes made of oligonucleotides or proteins (DNA chip and protein chip, respectively). Its main principle is that these probes will adsorb their corresponding DNA or RNA species. People want to learn more about these genes or proteins. Currently there are three ways to probe the technology, one is the synthesis spotting method, the first synthesis of oligonucleotides or oligopeptides, and then the way the pressure on the board. The second is to take the light-guided approach, so that oligonucleotide or oligopeptide slowly in the main plate synthesis. The third is similar to the inkjet printer operating mechanism, the oligonucle-

Gene microarrays have several uses: piecing together an unknown DNA sequence and understanding the performance of a gene. Introduce a relatively simple application. Piece together

First, the DNA of the sample is shattered one by one, and the double-stranded DNA is heated to single-stranded helical DNA. It is a long piece of DNA into a small short DNA sequence. It is the only ATGC single-stranded sequence. It attaches a special sequence of DNA Xs to each small piece of DNA (for example, five A at the beginning). It has a small platform with short pins that correspond to the DNA sequence of the X sequence. To the above example, is to pick

The system begins to release the same nucleotide one by one and then the next step. For example, it frees C to see what needle DNA will react to it. This is a reaction to give a light. It can shine a bright needle. It can be learned that the first nucleotide of these DNA sequences on these needles is G. The system is constantly repeating this step (of course, to release different kinds of nucleotides) to know the DNA sequence on this needle. Then go through a jigsaw

In cancer cell detection, gene microarray technology also has an important place. It can be used to compare the difference between normal cells and cancer cells. It can further find out

five T. In this way, these short DNA sequences are adsorbed onto these short needles.

puzzle-like step (using a computer as an aid) to spell out an entire sequence of DNA.

otide or oligopeptide materials Yiyi sprayed on the board gradually formed.

sequencing of DNA microarray chip.

the DNA sequence of the sample.

**3. Cell detection**

The design of the chip often starts from the system or encapsulation level and starts to reverse thinking. Whether the team has sufficient cross-communication between the fields except the experts in each field and jointly solve the problems derived from each other is often the relationship between chip design and The key to success or failure Therefore, different from the training requirements of traditional engineering technology, instead it is able to cross the field of micro-electromechanical systems, microfluidics systems, biomedical technology and optoelectronic technology and other fields, it is very important in the development of biomedical wafer.

When the amount of sample used to reduce, then faced with a sharp decline in signal detection problems. Increasing the signal strength or improving the sensitivity of the sensing device are two ways to solve the above problems. In terms of increasing signal intensity, there are currently artificial methods of replicating biomedical molecules to increase the weight of specimens, such as polymerization and per-chain reaction techniques; for those molecules that cannot be artificially increased, the number of markers for their markers or sensitivity, or to focus molecules in the detection area for detection. In enhancing the sensitivity of the sensing device, more sensitive new sensing technologies are also the focus of development besides reducing background noise.

In this project, the hot bubble liquid bead is generated by heating the liquid by using a microheating wire and generating bubbles of great thrust in a short time to push the liquid out to form micro-droplets, as shown in **Figures 3** and **4** below. In the quantification of biomedical microbeads, the integrity and cleanliness of the beaded pellets are often quantitatively

**Figure 4.** Gene microarray technology.

accurate or not. The way in which the foamed beads are produced will produce a series of beaded beads, that is, in addition to the main beaded beads, Subsequent satellite beads have a considerable degree of impact on accurate quantitation. The program has a complete set of main bead, quantitative determination of liquid beads, in line with biomedical specimens of liquid bead quantitative requirements, this study used to create disease detection and DNA sequencing of DNA microarray chip.

DNA micro-array, bio-chip or DNA chip combination of molecular, materials, motors and other fields of products. This system can be divided into DNA chip, protein chip, cell chip, tissue chip. However, only the first two are commonly used, in which a DNA chip can detect changes in the concentration of mRNA in a cell. The biggest advantage of gene microarrays is the ability to quickly and accurately provide a large number of genetic tests and to understand the performance of these genes. This is a considerable help in understanding the transmission of genes.

The main body of the chip is the use of glass, nylon, silicone, ceramic and other materials. Above there are probes made of oligonucleotides or proteins (DNA chip and protein chip, respectively). Its main principle is that these probes will adsorb their corresponding DNA or RNA species. People want to learn more about these genes or proteins. Currently there are three ways to probe the technology, one is the synthesis spotting method, the first synthesis of oligonucleotides or oligopeptides, and then the way the pressure on the board. The second is to take the light-guided approach, so that oligonucleotide or oligopeptide slowly in the main plate synthesis. The third is similar to the inkjet printer operating mechanism, the oligonucleotide or oligopeptide materials Yiyi sprayed on the board gradually formed.

Gene microarrays have several uses: piecing together an unknown DNA sequence and understanding the performance of a gene. Introduce a relatively simple application. Piece together the DNA sequence of the sample.

First, the DNA of the sample is shattered one by one, and the double-stranded DNA is heated to single-stranded helical DNA. It is a long piece of DNA into a small short DNA sequence. It is the only ATGC single-stranded sequence. It attaches a special sequence of DNA Xs to each small piece of DNA (for example, five A at the beginning). It has a small platform with short pins that correspond to the DNA sequence of the X sequence. To the above example, is to pick five T. In this way, these short DNA sequences are adsorbed onto these short needles.

The system begins to release the same nucleotide one by one and then the next step. For example, it frees C to see what needle DNA will react to it. This is a reaction to give a light. It can shine a bright needle. It can be learned that the first nucleotide of these DNA sequences on these needles is G. The system is constantly repeating this step (of course, to release different kinds of nucleotides) to know the DNA sequence on this needle. Then go through a jigsaw puzzle-like step (using a computer as an aid) to spell out an entire sequence of DNA.
