4. Origin of craniopharyngioma

Craniopharyngiomas were long thought to arise as an embryonic malformation from the anterior superior margin of the pituitary from residual Rathke's pouch. Due to their embryonic origin, they may even co-opt the blood supply of the wall and floor of the ventricle. More modern studies have demonstrated that aCP can arise due to paracrine actives of β-Catenin mutated cells, whereas pCP can arise via metaplastic transformation [2].
