**9. DIPG subgroups**

Proteomic, methylation and mRNA analyses have identified interesting subgroups of DIPG.

PDGFRA amplification is seen in association with H3.3 mutation and ACVR1 mutation is mainly seen in H3.1 mutant tumors [87, 115].

Upregulation of N-Myc and Hh signaling pathways [92].

Upregulation of N-Myc (H3 wild-type), silent genome and H3K27 M [115].

Mesenchymal transition with stem cell-like phenotype and oligodendroglial differentiation and PDGFRA amplification/mutation.
