*2.2.1. Direct oral anticoagulants*

Four non–vitamin K antagonist oral anticoagulants (NOACs), or direct oral anticoagulants (DOACs), are widely used as alternatives to warfarin: dabigatran etexilate, rivaroxaban, apixaban, and edoxaban. In contrast with warfarin, DOACs have a more predictable therapeutic effect, do not require routine INR monitoring, and have fewer potential drug-drug interactions and no restriction on dietary consumption of vitamin K–containing food [32].
