*2.2.3.1. Mechanism of action*

Sulodexide exerts a strong antithrombotic activity by simultaneously potentiating the antiprotease activities of both antithrombin III and heparin cofactor II. Sulodexide also has a profibrinolytic effect (through activation of tissue plasminogen activator and inhibition of plasminogen activator inhibitor), an antiproliferative effect on smooth muscle cells, and antilipemic and antiatherosclerotic effects [40, 41].
