*2.1.1.3. Pharmacokinetics*

After oral intake, warfarin enantiomers are absorbed rapidly and almost completely from the gastrointestinal tract (100% of bioavailability) and reach their maximal plasma concentration in 90 minutes in healthy people. Racemic warfarin is extensively bound to plasma protein (mainly albumin, 99%) and has a plasma half-life of 36–42 hours [9]. Warfarin is extensively metabolized in the liver by different CYP enzymes: CYP3A4 and CYP1A2 primarily metabolize the R-enantiomer, whereas the S-enantiomer is mainly metabolized by CYP2C9. The inactive metabolites are excreted with the urine and stool [10].
