**3.2. Components affecting fibrinolysis**

Fibrinolytic enzyme with metalloprotease activity has been described in the hard tick *I. scapularis* [176]. On the other hand, an activator of plasminogen, called longistatin from *H. longicornis*, was found to cause hydrolysis of fibrinogen and delay formation of the fibrin clot as comparable to that of tissue-type plasminogen activator (t-PA) [177]. The recombinant form of longistatins is able to inhibit inflammation associated to tick feeding [178].
