**Meet the editors**

Pınar Erkekoglu was born in Ankara, Turkey. She graduated from Hacettepe University Faculty of Pharmacy (BS). Later, she received her MSci and PhD degrees in toxicology. She completed a part her PhD studies in Grenoble, France in Universite Joseph Fourier and CEA/INAC/LAN after receiving full scholarship from both Erasmus Scholarship Program and from CEA. She

worked as a post-doc and a visiting associate in MIT Biological Engineering Department. She is working as an associate professor in Hacettepe University Faculty of Pharmacy Department of Pharmaceutical Toxicology since 2013. Her main interests are endocrine disrupting chemicals, oxidative stress and aromatic amines. She has published more than 140 papers in national and international journals. She is a European Registered Toxicologist (ERT) since 2014.

Belma Kocer-Gumusel graduated from Hacettepe University Faculty of Pharmacy. She received her PhD degree in toxicology in 1999. She worked as a postdoctoral fellow in Joseph Fourier University and CEA. She served as a faculty staff and retired as a full professor from Hacettepe University Faculty of Pharmacy. She now serves as the department head in Lokman Hekim

University Faculty of Pharmacy Department of Pharmaceutical Toxicology. Her main interests are endocrine diseases, oxidative stress and selenium. She has published more than 150 papers in national and international journals. She is a member of national and international scientific societies, including Turkish Society of Toxicology, EUROTOX and IUTOX. She is a European Registered Toxicologist (ERT) since 2011.

Contents

**Preface VII**

Pinar Erkekoglu

**Section 1 Glutathione - Evolution and Functions 1**

**Thiol-Redox Challenges 9**

**Glutaredoxin 2 (Grx2) 27**

**Section 2 Glutathione and Oxidative Stress 45**

Silva Reis

**Patients with Complications 47**

**Section 3 Glutathione and Central Nervous System 63**

**Nervous System 65** Juliana Echevarria Lima

Chapter 5 **The Role of Glutathione in Viral Diseases of the Central**

Chapter 1 **Introductory Chapter: A General Overview of Glutathione,**

**Glutathione Transport, and Glutathione Applications 3**

**Sulfur Reduction and Sulfide Oxidation to the Contemporary**

Chapter 2 **The Life Evolution on the Sulfur Cycle: From Ancient Elemental**

Roberto C. Burini, Hugo T. Kano and Yong-Ming Yu

Christy Xavier, Xiaobin Liu, Yang Liu and Hongli Wu

Chapter 4 **Impact of Oxidative Changes and Possible Effects of Genetics**

**Polymorphisms of Glutathione S-Transferase in Diabetics**

Laura Raniere Borges dos Anjos, Ana Cristina Silva Rebelo, Gustavo Rodrigues Pedrino, Rodrigo da Silva Santos and Angela Adamski da

Chapter 3 **The Important Functions of GSH-Dependent Enzyme**
