Contents

#### **Preface XIII**

#### **Part 1 Basic Science 1**


#### **Part 2 Clinical Aspects 103**


Contents VII

Chapter 19 **Hospital at Home for Elderly**

Chapter 22 **A Multi-Targeted Antisense** 

Chapter 23 **Cell Therapy in Chronic** 

**Patients with Acute Exacerbation of** 

Chapter 20 **Chest Mobilization Techniques for Improving** 

**Oligonucleotide-Based Therapy** 

Rosanne Seguin and Nicolay Ferrari

**Obstructive Pulmonary Disease: State of the Art and Perspectives 455** João Tadeu Ribeiro-Paes, Talita Stessuk and Rodrigo de las Heras Kozma

Donrawee Leelarungrayub

**Chronic Obstructive Pulmonary Disease 375** Aimonino Ricauda Nicoletta, Tibaldi Vittoria, Bertone Paola and Isaia Giovanni Carlo

Chapter 21 **Antipneumococcal Vaccination in COPD Patients 423**  Angel Vila-Corcoles and Olga Ochoa-Gondar

**Ventilation and Gas Exchange in Chronic Lung Disease 399** 

**Directed at Phosphodiesterases 4 and 7 for COPD 435**


#### **Part 3 Treatment 273**



VI Contents

Chapter 8 **Psychosocial Dimensions of**

Chapter 9 **Alpha-1 Antitrypsin Deficiency –** 

and Mohammad Towhidi

Chapter 12 **Chronic Obstructive Pulmonary** 

Chapter 13 **Evaluation of Dyspnea and** 

Chapter 14 **Adherence to Therapy in Chronic**

**Part 3 Treatment 273**

Cenk Kirakli

Chapter 17 **Noninvasive Positive-Pressure** 

Zeynep Zeren Ucar

Chapter 18 **Types of Physical Exercise**

Janice Gullick

**COPD for the Patient and Family 153**

**A Genetic Risk Factor for COPD 179** Tomás P. Carroll, Catherine A. O'Connor, Emer P. Reeves and Noel G. McElvaney

Chapter 10 **The Six-Minute Walk Test on the Treadmill 217**

Katarzyna R. Świda, Zbigniew W. Szczurek, Jerzy Gałecka and Agnieszka Winiarska

Chapter 11 **COPD Due to Sulfur Mustard (Mustard Lung) 231**  Shahrzad M. Lari, Davood Attaran

> **Disease and Diabetes** *Mellitus* **239**  Elisabet Martinez-Ceron, Beatriz Barquiel, Luis Felipe Pallardo and Rodolfo Alvarez-Sala

**Fatigue Among the COPD Patients 257**  Hatice Tel, Zeynep Bilgiç and Zübeyde Zorlu

**Obstructive Pulmonary Disease 275** Tamas Agh and Agnes Meszaros

Chapter 15 **Management of Acute Exacerbations 291** 

Chapter 16 **Novel Concept in Pulmonary Delivery 299**  Maria Carafa, Carlotta Marianecci, Paolino Donatella, Luisa Di Marzio,

> **Training for COPD Patients 351** R. Martín-Valero, A. I. Cuesta-Vargas and M. T. Labajos-Manzanares

Christian Celia, Massimo Fresta and Franco Alhaique

**Ventilation Therapy in Patients with COPD 333**

Fryderyk Prochaczek, Jacek S. Brandt, Witold Żmuda,


Preface

observation.

readers and the patients they are helping.

It is indeed heartening to note the ardent interest in Chronic Obstructive Pulmonary Disease (COPD) and the progress that has been achieved in the management of this disorder in recent years. A decade or so ago, many clinicians were described as having an unnecessarily 'nihilistic' view of COPD. This has certainly changed over the years, and the contributions that we have received from numerous distinguished sources as well as the keen anticipation for the publication of this book are testament to this

The 'open-access' format of this book provides a platform for scientists and clinicians from around the world to present their knowledge of the disease and up-to-date scientific findings, and avails the reader to a multitude of topics: from recent discoveries in the basic sciences to state-of-the-art interventions on COPD. This clearly reflects the wide-ranging academic interest in this disease. Indeed, those of us privileged to have a part in the management of patients with COPD will have known that this disease challenges the whole gamut of Respiratory Medicine – necessarily pushing frontiers in pulmonary function (and exercise) testing, radiologic imaging, pharmaceuticals, chest physiotherapy, intensive care with respiratory therapy, bronchology and thoracic surgery. In addition, multi-disciplinary inputs from other specialty fields such as cardiology, neuro-psychiatry, geriatric medicine and palliative care are often necessary for the comprehensive management of COPD. The recent progress and a multi-disciplinary approach in dealing with COPD certainly bode well for the future. Nonetheless, the final goal and ultimate outcome is in improving the health status and survival of our patients. With that in mind, I sincerely hope that this assemblage of subject reviews and novel insights on COPD will be of benefit for our

**Dr Kian-Chung Ong** 

Singapore

MBBS, MRCP (UK), FRCP (Edin), FCCP (USA)

Specialist - Respiratory Medicine, Mt Elizabeth Medical Centre

President, Chronic Obstructive Pulmonary Disease Association

Global Initiative for Chronic Obstructive Lung Disease (GOLD) National Leader
