**4. Conclusion**

NF-κB is one of the most important transcription factors and has an important role in inflammatory special lung disease [6]. The exact pathophysiological mechanism of NF-κB that leads to inflammation continues to be better understood. Pharmacologic therapy used for blocking this molecule can be useful for treatment of lung disease. The major recommendation for further research is to define the exact molecular mechanisms of each inflammatory lung disease that involves NF-κB. This is critical because the glucocorticoids which benefit patients with asthma do not work for COPD. Future research will to elucidate new methods of treatment for those patients [101].
