**Meet the editor**

After completing his basic medical education (MBBS) at the National University of Singapore in 1987, Dr Ong was accepted as a member of the Royal College of Physicians (MRCP) in the United Kingdom in 1993 and subsequently completed his specialist training in Respiratory Medicine at the Singapore General Hospital. In 1996 and 1997, Dr Ong was a Fellow in the Department of Pulmonary and

Critical Care Medicine, Stanford University Medical Center, USA, and was also a visiting clinical and research Fellow in the Stanford Sleep Disorders Clinic and Research Center, USA. Dr Ong has been in Edinburgh as a Fellow of the Royal College of Physicians (FRCP) since 2002. He is also a Fellow of the American College of Chest Physicians (ACCP). Dr Ong is the President of the Chronic Obstructive Pulmonary Disease Association (Singapore) and is recognized by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) as the National Leader in Singapore. He is presently in private specialist practice at the Mount Elizabeth Medical Centre, Singapore.

Contents

**Preface IX** 

Chapter 1 **Lung and Systemic Inflammation in COPD 3**  Abbas Ali Imani Fooladi, Samaneh Yazdani

**Disease: Emphysema Revisited 33** 

**Disease – Chaperonopathology 69**  Radostina Cherneva, Daniela Petrova

**Special Reference to Emphysema 117** 

Sudeepta Kumar Basu and Deepa Rastogi

and Mohammad Reza Nourani

Chapter 2 **Homocysteine is Elevated in COPD 21**  Terence Seemungal, Maria Rios

Nhue L. Do and Beek Y. Chin

**in the Pathogenesis of Chronic Obstructive Pulmonary Disease 47**  Emer Kelly and Caroline A. Owen

and J. A. Wedzicha

Chapter 3 **Chronic Obstructive Pulmonary** 

Chapter 4 **Diverse Activities for Proteinases** 

Chapter 5 **Chronic Obstructive Pulmonary** 

and Ognian Georgiev

Chapter 6 **COPD: Differential Diagnosis 105**  Maria Luisa Martinez Ortiz

**Part 2 Clinical Aspects 103** 

and Josep Morera

Chapter 7 **Current Overview of COPD with** 

Shantanu Rastogi, Amisha Jain,

**Part 1 Basic Science 1** 
