**Acknowledgements**

The authors would like to thank CONACYT for the financial support through CB-2016- 2101/286926 and Problemas Nacionales 2016-2101-2397 projects. They would also like to thank MC. Reina Aracely Mauricio-Sánchez for their technical support in chitosan experiments and MC. Lourdes Palma Tirado for their technical support in TEM imaging. Thanks to Dr. Lucero Granados-López and Dr. Rodrigo Muñoz-Acosta for their histochemical and pathology contributions in thermal burns treated with bio-nanocomposites.
