**1. Introduction**

Tissue regeneration is a vast subject, with many different important aspects to consider. From groundbreaking advances in the use of acellular dermal matrices, to the still-evolving stem cell treatments, this chapter provides an overview of the essentials in tissue regeneration science. We will explore the use of acellular dermal matrices, stem cell-based therapies, gene regulation, emerging 3D printing techniques and their potential applications in surgery and provide an overview of wound and tissue healing in general.
