Contents

**Preface XI**

### **Section 1 Using of Zebrafish in Medical Researches 1**

Chapter 1 **Zebrafish Aging Models and Possible Interventions 3** Dilan Celebi-Birand, Begun Erbaba, Ahmet Tugrul Ozdemir, Hulusi Kafaligonul and Michelle Adams

### Chapter 2 **Zebrafish Model of Cognitive Dysfunction 27** Brandon Kar Meng Choo and Mohd. Farooq Shaikh

Chapter 3 **Zebra Fitness: Learning and Anxiety After Physical Exercise in Zebrafish 45**

Mayara Silveira, Jonatas Silveira, Thais Agues-Barbosa, Miguel Carvalho, Priscila Silva and Ana Luchiari

Chapter 4 **The Roles of Estrogen, Nitric Oxide, and Dopamine in the Generation of Hyperkinetic Motor Behaviors in Embryonic Zebrafish (Danio rerio) 63**

Conor Snyder, Reid Wilkinson, Amber Woodard, Andrew Lewis, Dallas Wood, Easton Haslam, Tyler Hogge, Nicolette Huntley, Jackson Pierce, Kayla Ranger, Luca Melendez, Townsend Wilburn, Brian Kiel, Ty Krug, Kaitlin Morrison, Aaliayh Lyttle, Wade E. Bell and James E. Turner

Chapter 5 **Excitation and Excitation-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening 83** Matti Vornanen, Jaakko Haverinen and Minna Hassinen


Preface

Model organisms have been used in various disciplines in order to understand different mechanisms underlying the problems. It is well known that each discipline has its own set of organisms that have proven to be most suitable for the special research. Hence, there is a wide range of features searched for the model organisms such as rapid development with short life cycles, small adult size, ready availability, and tractability. From this point of view, the zebrafish has become a favorite model organism in different scientific research fields in recent years because of its rapid embryonic development, transparency of its embryos, and

*Recent Advances in Zebrafish Researches* demonstrates the role and the function of zebrafish in different research fields and totally includes 11 chapters, which have been written by the

Section I, "Using of Zebrafish in Medical Researches," is divided into six chapters. The first chapter, "Zebrafish Aging Models and Possible Interventions," debates on understanding of the underlying mechanisms and problems of age-related disorders using zebrafish as animal model. In this framework, neurobiological, perceptual, cognitive, and also genetic changes related with aging process are been discussed. The second chapter, "Zebrafish Model of Cognitive Dysfunction," provides valuable information regarding the use of zebrafish as an‐ imal model for cognitive dysfunction. From this point of view, necessary information on the definition of cognitive dysfunction, using different animal models for cognitive dysfunction with different aspects such as complex attention, executive function learning and memory, language, perceptual motor, and social cognition, is needed. In addition, some developed cognitive dysfunction tests for zebrafish are given. The third chapter, "Zebra Fitness: Learn‐ ing and Anxiety after Physical Exercise in Zebrafish," focuses on screening the cognitive abilities applying physical activities on zebrafish. The fourth chapter, "The Roles of Estro‐ gen, Nitric Oxide, and Dopamine in the Generation of Hyperkinetic Motor Behaviors in Em‐ bryonic Zebrafish (*Danio rerio*)," focuses on solving motor disorders in the brain using zebrafish as model organism, which shows similar neurological functions with humans that possess and can demonstrate damage symptoms. The fifth chapter, "Excitation and Excita‐ tion-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening," debates on ion current and ion channel compositions of zebrafish and hu‐ man ventricles in order to indicate similarities and differences between the fish model and the human heart. Finally, the sixth chapter, "Transient Receptor Potential (TRP) and Acid-Sensing (Asic) Ion Channels in the Sensory Organs of Adult Zebrafish," summarizes the cur‐ rent literature related to the role of ion channels involved in sensibility and opens new

expert researches in their fields. The book chapters are divided into three sections.

its large number of offspring along with several other advantages.

vision to detect some human pathologies.

### **Section 2 Using of Zebrafish in Toxicological Researches 119**

