**5.2. Functional protein arrays**

These arrays are mainly used for the characterization and identification the specific function of proteins, as well as their interactions with other molecules (including proteins, peptides, small molecules/drug, enzyme/substrates or nucleic acids,…) [12, 17]. Moreover, functional protein arrays also allow the detection and identification of post-translational modifications (PTMs), such as glycosylation, phosphorylation, acetylation,… which typically modulate the proteins' function, regulation and/or turnover.


**Table 1.** Advantages and limitations of protein microarrays in biomedicine.

Refers to research, functional protein arrays present the detection of multiple protein interactions with low reagent consumption in a fast and low cost fashion. On the translational side, the discovery of these interactions will promote the progress of new pharmaceutical targets, diagnostics and therapeutics. As a consequence, this technology is very interesting in the pharmaceutical industry [10] (**Table 1**).
