**Acknowledgements**

 We gratefully acknowledge financial support from the Spanish Health Institute Carlos III (ISCIII) for the grants: FIS PI17/01930 and CB16/12/00400. Fundación Solórzano FS/38-2017. The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023, of the PE I-+-D-+-I 2017-2020, funded by ISCIII and FEDER.-

### **Conflict of interest-**

The authors do not declare any conflict of interest.-
