**3. Results**

Serum levels of ADMA, Hcy, creatinine, LDL-C and hsCRP were significantly (p<0.001) higher in patients with mild CKD than in healthy controls. Also, systolic and diastolic blood pressures were increased (p<0.001). There were no significant differences in levels of serum fasting blood glucose, insulin, total cholesterol, HDL-C, triglyceride, calcium and phosphate between the mild CKD and healthy controls (P>0.05). Serum NO and creatinine clearance levels were decreased in patients with mild CKD than in healthy controls (p<0.001). Clinical and laboratory data are reported in Table 1. In multiple linear regression analysis, ADMA level was negatively correlated with NO (r = -0.861; p<0.001) as shown in Figure 2A, and positively correlated with Hcy (r = 0.547; p<0.001, Figure 2B) and fibrinogen (r = 0.704; p<0.01, Figure 2C). ADMA level was positively correlated with creatinine (r=0.510;p<0.001), LDL-C (r=0.420;p<0.01), hsCRP (r=0.525;p<0.001), systolic (r=0.375; p<0.001) and diastolic blood pressure (r=0.410;p<0.001) levels. ADMA level was negatively correlated with GFR (r=-0.720;p<0.001). Also, serum NO level was negatively correlated with homocystein (r = - 0.390; p<0.001, Figure 3). We found no association between ADMA and HDL-C or other parameters in either subjects with mild CKD.
