**6. Effects of HE-86 administration on biochemical parameters in uraemic rats**

Table2-3 shows the summary of renal function and 24h urine protein level. There was significant change in body weight between the control uraemic (control) and HE-86 treated uraemic (treatment) rats, although they were pair-fed. body weight of treatment group was showed more than control uraemic. Even 4 weeks after 5/6-nephrectomy, the levels of serum creatinine and BUN were markedly increased as compared to sham rats. Not only at 4 week but also at 8 week, the uraemic rats treated with HE-86 were manifested significantly decreased levels of serum creatinine, BUN, respectively. Urinary protein excreation was also suppressed obviously at 8 week as comparing with control uraemic rats.


Table 2. Serum creatinine and blood urea nitrogen after 4 week treatment. #P<0.05, ##P<0.01,when compared against empty vector-treated controls


Table 3. Serum creatinine, blood urea nitrogen and twenty-four-hour urinary protein excretion after 8 week treatment. #P<0.05, ##P<0.01,when compared against empty vectortreated controls
