Contents

**Preface XI**


Chapter 5 **Hepatic Trauma 97** Ali Ibrahim Yahya

#### **Section 4 Hepatocellular Carcinoma 111**

Chapter 6 **Molecular Mechanisms of Hepatocellular Carcinoma Related to Aflatoxins: An Update 113** Xi-Dai Long, Yan Deng, Xiao-Ying Huang, Jin-Guang Yao, Qun-Ying Su, Xue-Min Wu, Juan Wang, Qun-Qing Xu, Xiao-Ying Zhu, Chao Wang, Bing-Chen Huang and Qiang Xia

Preface

clearly emphasized.

all the editorial processes.

It is my pleasure and a great honor for me to present you this new book from the area of medicine, hepatology section entitled *Liver Research and Clinical Management* that could be described as the application of basic and experimental as well as clinical research and its application to the treatment of human liver diseases in the daily clinic. It is what has been applied in other words to the transfer of knowledge from the bench to the bed, applied to

This book is divided into several sections that treat problems related to different diseases including topics on "nonalcoholic fatty liver disease" that is an increasingly common prob‐ lem especially in developed countries like a large epidemic disease, mainly in relation to the obesity and bad food habits of the population. In another section, the authors describe the important role of the "imaging evaluation of the liver" in the diagnosis and control of differ‐

Other sections are devoted to "hepatic trauma" that appears as a consequence of the open or close accidents around or inside this important organ, the way of early detection, and surgi‐ cal repair. "Hepatocellular carcinoma" is the most common primary tumor of the liver that appears commonly associated to liver cirrhosis of long duration, whose diagnosis is some‐

Liver transplantation is commonly used as the therapy of choice for patients who have a liver advanced insufficiency or end-liver disease. There is a long experience all over the world with this procedure that provides and restores a good quality of life on the receptor that needs a long-term immunosuppression to avoid the rejection. Usually, the liver donor came from a cadaver, but the shortage of donations has introduced the possibility of living donors of the liver as another important source for providing livers for transplantation.

Another possibility of restoring the liver function is to use the "gene therapy" that is ad‐ vancing a lot in recent years but needs to continue improving its results. The "psychosocial aspect evaluation" of all these therapies and the impact on the patients and their families are

Finally, I want to thank all the authors for their excellent contributions and the InTech edito‐ rial team and especially Ms. Romina Skomersic, for her continuous collaboration and kind support in the total book preparation and her help and easily resolving all my needs during

**Prof. Luis Rodrigo, MD**

University of Oviedo Oviedo, Spain

Emeritus Full Professor of Medicine

liver diseases, that have been occurring in recent decades.

ent problems related to the liver and the biliary tract.

times difficult, and the several ways of treatment are described.

