**3. Hemophilia**

Hemophilia is an inherited bleeding disorder, caused by the deficiency of procoagulants. Deficiency of FVIII is known as hemophilia A, deficiency of FIX is known as hemophilia B and deficiency of FXI is known as hemophilia C [13–17]. The hemophilia A and B are X chromosome linked disorders and they are mainly observed in the male population [14, 15, 17]. Hemophilia A cases are observed in 1 in 5000 males whereas, hemophilia B cases are observed in 1 in 20,000 males (https://www.hemophilia.org/About-Us/Fast-Facts). Hemophilia is classified based on the functional antigen levels. Patients with <1% activity with spontaneous bleeding are termed as severe hemophilia, patients with 1–5% activity are called moderate hemophilia and individuals with >5%, <40% are termed as mild hemophilia [17].
