*4.1.9. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio*

Neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios, as indicators of subclinical inflammation, rarely were been investigated in SCD patients. Emokpae et al. [138] recently reported a positive association between NLR, PLR and the increase of inflammatory markers in SCD patients such as C-reactive protein (CRP) and fibrinogen. The highest values of NLR and PLR were detected in patients with proteinuria and altered renal function. This data suggest that these markers may be predictive of a proinflammatory state with underlying renal damage.
