**Meet the editors**

Professor Dr. Margarita Guenova received her medical training at the Medical University of Sofia and her PhD degree at the National Center of Haematology in 2000. She is employed as the head of the Laboratory of Haematopathology and Immunology and a professor of Haematology and Blood Transfusion at the National Specialised Hospital for Active Treatment of Haemato-

logical Diseases, Sofia, Bulgaria, teaching both undergraduate and graduate studies at the Medical University of Sofia. She specializes in the field of leukemia and lymphoma diagnostics. In regard to her scientific interests, she worked on the elucidation of critical mechanisms of leukemia pathogenesis and progression, investigation of clinically relevant biomarkers and potential targets for therapy in leukemias and lymphomas, characterization of leukemic stem cell populations, minimal residual disease, and implementation of a multifaceted approach in oncohematology. Dr. Guenova has authored and coauthored many abstracts, articles in peer-reviewed journals, and book chapters. She serves on editorial boards and is the president of the Bulgarian Society of Hematology, as well as a member of several professional societies such as the Bulgarian Society of Pathology, the Bulgarian Association of Clinical Immunology, the European Hematology Association, the European Association of Hematopathology, and the International Society of Hematology.

Professor Dr. Gueorgui Balatzenko received his medical training at the Medical University of Sofia and his PhD degree at the National Center of Haematology in 2002. He obtained additional qualifications at the Red Cross Blood Bank, Groningen-Drenth, the Netherlands; Institute Paoli-Calmettes Marseille, France; and Hôpital Necker-Enfants Malades, Paris, France. He is employed

as the head of the Laboratory of Cytogenetics and Molecular Biology and a professor in the Department of Haematology and Blood Transfusion at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria, teaching both undergraduate and graduate studies at the Medical University of Sofia. His major interests are in the field of molecular investigations in leukemias. In regard to his scientific achievements, he worked on the elucidation of the incidence and clinical relevance of molecular biomarkers in chronic and acute leukemias and molecular monitoring of treatment response. Dr. Balatzenko has authored and coauthored many articles in peer-reviewed journals and book chapters. He is a member of several professional societies such as the Bulgarian Society of Hematology and the Bulgarian Society of Genetics, a lifetime member of the UICC, and a referee for international journals.

Contents

**Preface VII**

**Innovation 3**

Navarrete

**Leukemia 95**

Bhaskar Kahali

**Section 2 Hematological Malignancies 15**

Chapter 1 **Introductory Chapter: Hematology in Times of Precision and**

Gueorgui Balatzenko and Margarita Guenova

Chapter 2 **The Antigen Receptor as a Driver of B-Cell Lymphoma**

Chapter 3 **Recent Advances in Diffuse Large B Cell Lymphoma 39**

Sridurga Mithraprabhu and Andrew Spencer

Chapter 5 **Quantitative-Morphological and Cytological Analyses in**

Chapter 6 **Myeloid Sarcoma: The Other Side of Acute Leukemia 115**

Cecília Lantos, Steven M. Kornblau and Amina A. Qutub

Julieta Sepulveda, Noé Seija, Pablo Oppezzo and Marcelo A.

Vivek Kumar, Sarvadaman Makardhwaj Shrivastava, Trishala

**Development and Evolution 17**

Meghal and Binod Abhinav Chandra

Chapter 4 **Liquid Biopsy in Multiple Myeloma 73**

**Section 1 Introduction 1**
