**5. Hormonal therapy**

The occasional response of patients with metastatic RCC to hormonal therapy with medroxyprogestrone acetate (MPA) provided a rationale in trying it in adjuvant sitting.

In a prospective randomized trial of adjuvant MPA after radical nephrectomy, 136 patients received either MPA 500 g (three times a week) for 1 year or observation. With a median follow up of 5 years. There were no significant differences in relapses between the adjuvant group and the observation group (32.7 vs. 33.9%, respectively) [44].
