**Acknowledgements**

Work in our laboratory is supported by grants provided by the São Paulo Research Foundation (CETICs 2013/07467-1 and 2015/50040-4, São Paulo Research Foundation and GlaxoSmithKline). The authors thank the National Counsel of Technological and Scientific Development (CNPq, INCTTox), Coordination of Improvement of Higher Education Personnel (CAPES), BNDES 13.2.0711.1/2013, and União Química Farmacêutica Nacional for the support.
