**4. Conclusions**

The HPV is not a sufficient cause for developing of cervical cancer, therefore other factors may be involved in this susceptibility, namely the microenvironment in vagina and inter-individual genetic polymorphic variations. These variables must be integrated in a complex model that integrates other co-factors, such as, smoking, diet and oral contraceptives. According to this review based on recent data, it seems that a deficiency of an antioxidant mechanism associated to a compromise vaginal microflora and inefficient genetic profile may contribute to the development of cervical cancer. We hypothesis that the genetic background and dysbiosis may contribute to increase risk for gynecologic advanced cancer.

Therefore, the equilibrium of gut/vaginal microbiota and adequate supplementation for a homeostasis of oxidant and antioxidant species may contribute to the regression of the persistence of factors associated with cervical cancer.
