*2.2.5. Corticobasal degeneration*

Corticobasal degeneration (CBD) is an adult variable dementia and neurodegenerative syndrome. This is a sporadic disease accounting for one per million cases of dementia per year; the incidence of CBD is ten times lesser than that of Parkinson's disease [124]. In case of CBD, filamentous inclusions in neurons and glia having selective accumulation of hyperphosphorylated four microtubule-binding repeat tau (4R-tau) are seen [125]. The tau H1 MAPT haplotype is also stalwartly related with CBD pathology, just as it is with PSP [120].
