*2.2.4. Frontotemporal dementia with Parkinsonism associated with chromosome 17 (FTDP-17)*

Frontotemporal dementia with Parkinsonism associated with chromosome 17 (FTDP-17) is a neurological disorder that is a part of frontotemporal dementia, categorized by a damage of the neuron in the frontal and temporal lobes of the brain. A loss of these cells can affect personality, behavior, speech and cause motor disturbances. Mutations in the tau gene can cause this dementia. 32 tau gene mutations have been recognized in over 100 families of this syndrome [123]. Tau gene mutations associated with FTDP-17 cause anomalous filament development and an amassing of tau in neuronal and glial cells in the cerebral cortex and in the nuclei of subcortical cells. Tau mutations alter tau isoforms in FTDP-17. The mechanisms of the modifications that lead to neuronal death are yet to be discovered.
