**2.2. Analysis of parameters of neurospecific proteins in patients with type 1 diabetes mellitus**

As a result of the analysis, a significant increase in all studied proteins was revealed in patients with type 1 diabetes mellitus, S100, MBP, and GFAP, compared to the control group (p < 0.001) (**Table 2**).

The levels of neurospecific proteins, depending on the duration of the disease, had fluctuations. So, the S100 protein was higher in patients with a short duration of the disease (1–4 years) and the smallest with duration of the disease for more than 15 years. While MBP had an equally stable level in patients with different durations of type 1 diabetes mellitus. The fluctuations in the level of GFAP were also insignificant and tended to decrease with increasing duration of the disease. According to our study, in women, the level of GFAP was significantly lower than in men (U = 643.0, z = −2.4, p < 0.05).


Note: The significance of differences between the control group and patients with type 1 diabetes mellitus at the level: \* p < 0.01.

**Table 2.** Characteristic levels of neurospecific proteins in patients with type 1 diabetes mellitus and the control group.
