**4. Tauopathy treatment**

To date, no drug targeting tauopathies has entered the market [147]. Over the past two decades, a dozen representative drugs have been pursued in the clinical trials [148], and these drugs represented the major therapeutic approaches in tauopathy treatment, including tau aggregation inhibitors, tau phosphorylation-related kinase inhibitors, microtubule stabilizers, and immunotherapy against tau. However, since these strategies have yet to show significant benefit, new approaches are being probed, among which a scheme to enhancing protein homeostasis is an intriguing approach [147, 149]. Other alternative approaches including using traditional Chinese medicine are also being pursued [150].
