**5. Conclusion**

In this chapter, we discussed major basic aspects of tauopathy, from tau normal functions to pathology formation process and from tau genetic mutations to posttranslational modifications. Finally, we discussed currently proposed tauopathy treatment methods. With the findings showing tau proteins are involved in many brain pathology conditions beyond tauopathy and more evidences showing the roles of tau in Alzheimer's disease are critical, it is expected to receive more basic research attentions in the future [167, 168]. Better animal models tailored for different tauopathy are of pursuit, which will benefit both basic research and clinical drug developments.

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