**Anticorrosive, Antimicrobial, and Bioactive Titanium Dioxide Coating for Surface‐modified Purpose on Biomedical Material**

Hsi‐Kai Tsou and Ping‐Yen Hsieh

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.68854

#### **Abstract**

[187] Lee JC, Park KS, Kim TG, Choi HJ, Sung YM. Controlled growth of high-quality TiO<sup>2</sup>

[188] Ma R, Fakuda K, Sasaki T, Osada M, Bando Y. Structural features of titanate nanotubes/ nanobelts revealed by Raman, X-ray absorption fine structure and electron diffraction

[189] Amin SS, Nicholls AW, Xu TT. A facile approach to synthesize single crystalline rutile

[190] Mukherjee K, Teng TH, Jose R, Ramakrishna S. Electron transport in electrospun TiO<sup>2</sup> nanofiber dye-sensitized solar cells. Applied Physics Letters. 2009;**95**:012101

[191] Fujihara K, Kumar A, Jose R, Ramakrishna S. Spray deposition of electrospun TiO<sup>2</sup>

[192] Kisumi T, Tsujiko A, Murakoshi K, Nakato Y. Crystal-face and illumination intensity dependences of the quantum efficiency of photoelectrochemical etching, in relation to

[194] Dinan B, Akbar S. One dimensional oxide nanostructures by gas-phase reaction.

arrays grown directly on a Ti metal self-source substrate. Journal of Nanoscience and

ires by oxidation of titanium substrates in the presence of ethanol vapor. Scripta

nanowire surfaces formed by thermal oxidation of titanium

[197] Tan AW, Ismail R, Chua KH, Ahmad R, Akbar SA, Pingguan-Murphy B. Osteogenic

[198] Pu Y-Ch, Wang G, Chang K-D, Ling Y, Lin Y-K, Fitzmorris BC, Liu Ch-M, Lu X, Tong Y, Zhang JZ, Yung-Jung Hsu Y-J, Li Y. Au Nanostructure-decorated TiO<sup>2</sup>

[199] Stengl V, Bakardjieva S, Murafa N, Vecernıkova E, Subrt J, Balek V. Preparation and characterization of titania based nanowires. Journal of Nanoparticle Research.

exhibiting photoactivity across entire UV-visible region for photoelectrochemical water

(rutile) semiconductor electrodes. Journal of

nanowires on Ti and Ti

nanowires

nanow-

nanowires

one-dimensional nanostructures. Nanotechnology. 2007;**18**:445609

nanowires on sapphire and silica. Nanotechnology. 2006;**17**:4317-4321

characterizations. Journal of Physical Chemistry B. 2005;**109**:6210-6214

nanorods for dye-sensitized solar. Nanotechnology. 2007;**18**:365709

alloys by oxidation. Journal of Nanomaterials. 2010;**7**. Article ID 503186

[195] Huo K, Zhang X, Fu J. Synthesis and filed emission properties of rutile TiO<sup>2</sup>

[196] Daothong S, Songmee N, Thongtem S, Singjai P. Size-controlled growth of TiO<sup>2</sup>

those of water photooxidation, at *n*-TiO<sup>2</sup>

Electroanalytical Chemistry. 2003;**545**:99-107

Functional Nanomaterials Letters. 2009;**2**:87-94

Nanotechnology. 2009;**9**:3341-3346

Materialia. 2007;**57**:567-570

potential of in-situ TiO<sup>2</sup>

2007;**9**:455-470

[193] Lee H, Dregia S, Akbar S, Alhoshan M. Growth of 1-D TiO<sup>2</sup>

alloy surface. Applied Surface Science. 2014;**320**:161-170

splitting. Nano Letters. 2013;**13**:3817-3823

TiO<sup>2</sup>

102 Application of Titanium Dioxide

A multifunctional titanium dioxide (TiO2 ) coating was used to provide anticorrosive, antimicrobial, and bioactive properties for the surface modification of biomedical materi‐ als because TiO2 has a stable bonding structure, photocatalytic characteristics, and nega‐ tively charged surfaces in nature. For successful deposition, an arc ion plating technique was adopted to deposit the TiO2 coating. The antimicrobial activity values of anatase‐ TiO2 ‐coated stainless steel specimens against *Staphylococcus aureus* and *Escherichia coli* were 3.0 and 2.5, respectively, which are far beyond the value designated in JIS Z2801:2000 industrial standard. TiO2 coatings on stainless steel also generate an increased (i.e., less negative) corrosion potential and decreased corrosion current in a sodium chloride solu‐ tion, showing a reduced tendency and rate of substrate dissolution as well as a reduced coating of species into the electrolyte. In addition, TiO2 coatings, especially with rutile phase, satisfied the requirements for activating the biological property of a polymeric polyetheretherketone surface. Therefore, TiO2 is a promising surface modification for the biomedical materials used in surgical instruments and implants.

**Keywords:** anticorrosive, antimicrobial, bioactive, titanium dioxide, biomedical material
