**5.5. Dorsal striatum**

Recent studies documented that deep brain stimulation of the dorsolateral caudate/putamen significantly attenuates cocaine seeking following chronic cocaine self-administration and withdrawal in rats [61] and also an increase of gray matter in both the ventral and the dorsal striatum in human addicts [62]. The application of DBS in the dorsal striatum may induce undesirable hypokinetic symptoms similar to Parkinson's disease symptoms due to the spread of current to the close motor regions.
