Contents

### **Preface XI**


Preface

Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a

disruption of the intracellular redox balance and the homeostatic balance between cellular

oxidants and antioxidants. Reactive oxygen species (ROS), although essential for normal

physiologic processes, are deleterious when produced in excess. Free radicals include not only

ROS but also reactive nitrogen species (RNS) such as nitric oxide and peroxynitrite similarly

leading to nitrosative stress. These molecules react with molecular targets including proteins,

This book intends to provide the readers with an extensive overview of the novel ap‐

proaches and prospects based on oxidative and nitrosative stress in the pathophysiology of

various diseases and in the current treatment strategies with antioxidants, and it is the one

I believe that this book will provide a good grounding in pointing the way to new disciplines

that will contribute to the evolution of strategies for creating, analyzing, and presenting the

**Prof. Dr. Pinar Atukeren**

Cerrahpasa Medical Faculty

Department of Medical Biochemistry

Istanbul University

Turkey

medical information in the future stimulating our colleagues at all multidisciplinary levels.

lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction.

to which the authors have made significant contributions in all chapters.
