**Meet the editors**

Dr. Waldely Dias graduated in Biomedical Sciences at the Federal University of São Paulo (1977) and obtained her Master's degree (1981) and PhD (1983) in Microbiology and Immunology at the same university. She has completed post-doctoral fellowship at the Institut Pasteur Paris, in the Laboratory of Biotechnologies - Hybridolab (1987) and at the Food and Drug Administration

(FDA) - Laboratory of Pertussis, USA (1992). As a senior scientific researcher of the Biotechnology Center at the Butantan Institute (now Special Laboratory of Vaccine Development) since 1988, Dr Dias is involved in the development of new bacterial vaccines, including a whole cell pneumococcal vaccine and new alternatives for pertussis vaccines.

Dr. Isaias Raw graduated in Medicine at the São Paulo University (1950), having been professor of Physiological Chemistry at the Faculty of Medicine of the same University. Previous Director of Butantan Institut (1991-1997) and President of the Butantan Foundation (1998 – 2009). He founded the Biotechnology Center of the Butantan Institute, where he was director for 19

years (1983 – 2002). He has been dedicated for more than thirty years to the development of vaccines and pharmaceutical products by Butantan Institution, in production processes that result in products to be made available to the Ministry of Health of Brazil, for free use to the population.

Contents

**Preface VII**

**Challenges 3** Waldely Dias

**Response 9**

**Pertussis 11** Daniela Hozbor

**Vaccination Rate 25**

**Section 3 Current Pertussis Vaccines and Strategies 43**

Chapter 1 **Introductory Chapter: Pertussis - Disease, Control and**

Chapter 2 **Update on Epidemiology, Diagnosis, and Treatment of**

Chapter 3 **Clinical Experiences in Pertussis in a Population with High**

Chapter 4 **Preventive and Protective Properties of Pertussis Vaccines: Current Situation and Future Challenges 45** De-Simone SG, Provance DW and Rocha da Silva F

Chapter 5 **Pertussis Immunization in Pregnancy: A Review 63**

de Ulhôa Escobar and Sandra Josefina Ferraz Ellero Grisi

Giovanni Gabutti, Armando Stefanati and Parvanè Kuhdari

Filumena Maria da Silva Gomes, Maria Helena Valente, Ana Maria

**Section 2 Pertussis - Epidemiology, Diagnosis, Treatment and Immune**

**Section 1 Introduction 1**
