Chapter 8 **Role of Cytotoxicity Experiments in Pharmaceutical Development 131**

Ildikó Bácskay, Dániel Nemes, Ferenc Fenyvesi, Judit Váradi, Gábor Vasvári, Pálma Fehér, Miklós Vecsernyés and Zoltán Ujhelyi

Preface

different parts:

• Cytotoxicity of chemicals

• Cytotoxic endpoints

important for human health.

cine derivatives, and docking studies.

the population.

• Cytotoxic effects of natural substance

• Nanomaterials, nanoparticles, and nanocrystals

The book "Cytotoxicity" is a web-based resource, encompassing some of the natural cyto‐ toxicity and different chemical substances, such as natural coumarins, colchicine alkaloids, titanate nanosheets, asbestos fiber, nanomaterials, nanocrystals and composites, and curcu‐ min-loaded copolymer encapsulated ZnO nanocomposites. This e-resource comprises four

The first chapter, by Dr. Takemi Otsuki et al. from Japan, describes the different perspec‐ tives of "cytotoxicity caused by asbestos fiber and acquisition of resistance by continuous exposure in human T cell." Considering the most important issue of asbestos-exposed popu‐ lation, such as malignancies, namely, mesothelioma and lung cancer after the long-term la‐ tent period, the mechanisms should be explored as well as be prevented. This issue is

The second chapter "The Cytotoxic, Antimicrobial, and Anticancer Properties of Antimicro‐ bial Nisin Z Alone and in Combination with Conventional Treatments," by Dr. Johannes Wentzel et al. from North-West University, South Africa, highlights the cytotoxic, antimicro‐ bial, and anticancer properties of antimicrobial nisin Z alone and in combination with con‐ ventional treatments, and they discussed the anticancer potential of nisin Z toward cultured melanoma cells, hence advocating safety and caution regarding their indiscriminate use by

The third chapter "Cytotoxic Colchicine Alkaloids: From Plants to Drug," by Dr. Joanna Kurek, Chemistry Department, Adam Mickiewicz University, Poznań, Poland, deals with the plants of Liliaceae family that contains colchicine; colchinoids; natural, semisynthetic, and synthetic colchicines; and C-10 sulfur-containing derivatives as a main alkaloid, which has cytotoxic activity and cytotoxic activity of colchicine and its derivatives. Furthermore, we have provided information on the pharmacological use of colchicine, drugs with colchi‐

The fourth chapter, by Abdelmajid Zyad et al. from Morocco, discusses some examples of carvacrol, thymol, carveol, carvone, eugenol, isopulegol, and artemisinin as well as polyphe‐ nol extracts that have been studied in their laboratory. It is clear that if we understand the

### **Section 5 Nanomaterials and Nanoparticles and Nanocrystals 147**

### Chapter 9 **Biocompatibility of Doped Semiconductors Nanocrystals and Nanocomposites 149**

Anielle Christine Almeida Silva, Mariana Alves Pereira Zóia, Lucas Ian Veloso Correia, Fernanda Van Petten Vasconcelos Azevedo, Aline Teodoro de Paula, Larissa Prado Maia, Layara Santana de Carvalho, Loyna Nobile Carvalho, Maria Paula Camargo Costa, Layssa Carrilho Giaretta, Renata Santos Rodrigues, Veridiana de Melo Ávila, Luiz Ricardo Goulart and Noelio Oliveira Dantas

#### Chapter 10 **Toxicity of Titanate Nanosheets on Human Immune Cells 163** Yasumitsu Nishimura, Daisuke Yoshioka, Naoko Kumagai-Takei, Suni Lee, Hidenori Matsuzaki, Kei Yoshitome and Takemi Otsuki

Chapter 11 **General Cytotoxicity and Its Application in Nanomaterial Analysis 177** Magdalena Jedrzejczak-Silicka and Ewa Mijowska
