**3. Conclusion**

The cytotoxicity analysis of Ag or Ca doped ZnO NCs in normal, tumor prostate and breast cells was possible to identify the antitumor effect potentialization when these ions (Ag and Ca) were incorporated into ZnO NCs. In this way, these doped NCs can become a target in the treatment of cancer. The viability assay against microorganisms showed that the increase of Eu doping in ZnO NCs promoted the growth of the microorganisms and Ni doped ZnO with NiO NCs are more efficient than NiO NCs to *K. pneumonia.*
