5. Conclusions

NIHL, presbycusis, ototoxic hearing loss, and hearing loss associated with CKD may seem disconnected and quite different from one another, but oxidative stress emerges as a paradigm that helps reassess the reasoning behind these losses and better understand the environment of the cochlea when exposed to harmful intrinsic and extrinsic factors.

It is hoped that this new paradigm for the different hearing losses will result in a different approach to the physiological changes that affect the auditory system in the form of high-frequency hearing

loss. As such, preventing, treating, and avoiding exacerbations are possibilities to be investigated in order to guarantee efficient communication and quality of life for individuals.
