**11. Final comments**

The aim of this chapter is to emphasise the major role of muscle spindles in muscle pain. Inflammatory muscle diseases with major histopathological changes are usually not associated with muscle pain. On the other hand, another disease with minor histopathological changes, the myofascial syndrome, may have severe muscle pain and local tenderness to pressure in TrPs. This fact can be explained by inflammation and pain elicited in the muscle spindles. Painful spots in needle EMG may simply be muscle spindles with nociception. Polymyalgia rheumatica may be associated with interstitial muscle pain. It remains to be studied whether there is also pain caused by inflammation of the muscle spindle capsules. DOMS may express both interstitial pain and muscle spindle pain with mild intrafusal inflammation.
