**4. Conclusions**

HCC is a frequent and aggressive malignant tumour. Longer survival can be reached in early diagnosed and properly treated cases. In the future, diagnosis of HCC might be based on combination of radiological features and miRNA profile representing liquid biopsy. MiRNA profile can have both diagnostic and prognostic value. Thus, further lowering of the needs for core biopsy might be expected, leading to patient-friendly examination and avoiding the rare but still possible complications. After the diagnosis of HCC has been confirmed, SIR assessment by NLR and PLR represents innovative means of prognostic evaluation.
