**Acknowledgements**

This work was supported by grants-in-aid from Projects of the National Natural Science Foundation (81673241, 81702419), the Jiangsu Health Plans (2014-YY-028 and BE2016698), the Jiangsu Graduate Innovation Plan (KYCX17\_1934), the Nantong Science Foundation of Health and Family Planning Commission (WQ2016083), and the International Science & Technology Cooperation Program (2013DFA32150) of China.
