**3. Conclusion**

HCC is a complex pathogenesis link with various risk factors. Liver cirrhosis is, unsurprisingly, an important risk factor for HCC development, regardless of the cause, whereas chronic HBV and HCV infections are the most significant developing factors for liver cancer worldwide. Therefore, frequent causes of cirrhosis are indicated as risk factors for HCC. The common factors affecting the progression to HCC in patients with cirrhosis are host and viral related with the involvement of external risk factors such as smoking, alcohol, and aflatoxins.
