**Conflicts of interest and source of funding**

The authors declare no competing financial interests. This study was supported in part by the National Natural Science Foundation of China (nos. 81760502, 81572353, 81372639, 81472243, 81660495, and 81460423), the Innovation Program of Guangxi Municipal Education Department (nos. 201204LX674 and 201204LX324), Innovation Program of Guangxi Health Department (no. Z2013781), the Natural Science Foundation of Guangxi (nos. 2017GXNSFGA198002, 2017GXNSFAA198002, 2016GXNSFDA20380003, 2015GXNSFAA139223, 2013GXNSFAA019251, 2014GXNSFDA20118021, and 2014GXNSFAA118144), the Youth Natural Science Foundation of Guangxi Medical University (no. GXMUYSF201522), Research Program of Guangxi "Zhouyue Scholar" (no. 2017–38), Research Program of Guangxi Specially Invited Expert (no. 2017-6th), Research Program of Guangxi Clinic Research Center of Hepatobiliary Diseases (no. AD17129025), and Open Research Program from Molecular Immunity Study Room Involving in Acute & Severe Diseases in Guangxi Colleges and Universities (nos. kfkt20160062 and kfkt20160063).
