**7. Conclusion**

New therapeutic options are needed for the treatment of HCC despite the availability of sorafenib, which has limited survival benefits in advanced HCC patients. Several clinical trials are investigating the efficacy and tolerability of combining sorafenib with other agents. Future studies should continue to delineate dysregulated signalling pathways in hepatocarcinogenesis to introduce new molecular targets for therapeutic intervention. Simultaneously it is critical to identify biomarkers and/or aberrant genotypes that would predict clinical efficacy to these targeted agents. Much work also remains to evaluate the role of targeted therapy in adjuvant, neoadjuvant or metastatic settings to determine the most suitable combination of treatment. The battle against HCC is far from over and requires a multidisciplinary approach.
