**Meet the editors**

Costin Teodor Streba, MD, PhD, MSc, is an Associate Professor at the University of Medicine and Pharmacy of Craiova. He is a member of the Research Center of Gastroenterology and Hepatology of Craiova, within the same university. He has undertaken research in the field of liver and pancreatic disease diagnostics, while also receiving extensive training in histological image

analysis. He specialized in devising medical-oriented diagnostic systems for liver malignancies, which integrate interpretation and computer-aided quantification of various imaging and clinical data. His publication record reflect his dedication for innovative diagnostic techniques in gastroenterology, having numerous large-scale studies featured in various high-impact publications within this field.

Cristin Constantin Vere, MD, PhD, MSc, is a Professor of Gastroenterology at the University of Medicine and Pharmacy of Craiova and one of the founding members of the Research Center of Gastroenterology and Hepatology of Craiova. His research interests span from neuroimmune mechanisms of liver disease to novel diagnostic techniques in gastroenterology. Pioneering the introduc-

tion of wireless videocapsule in Romania, he established a dynamic team of PhD students and full-time scientists that specialized in both medical sciences and bioinformatics. His publication record attests to his dedication for innovation in the field of hepatology and the complex integrative mechanisms that form the basis for this pathology.

Ion Rogoveanu, MD, PhD, MSc, is a Professor of Gastroenterology at the University of Medicine and Pharmacy of Craiova and one of the founding members of the Research Center of Gastroenterology and Hepatology of Craiova. He mentors a team of dedicated doctors and manages the curricular and scientific activities of the University as Rector. He is currently one of the lead au-

thorities in Ultrasound and Power Doppler US, coordinating postgraduate courses for the past 10 years. His most prestigious recent publications are all in the field of prevention, diagnosis and treatment of HCC and various liver diseases.

Contents

**Preface VII**

Chapter 1 **Introductory Chapter: Etiology and Pathogenesis of**

Costin Teodor Streba, Cristin Constantin Vere, Ion Rogoveanu and

Dzeina Mezale, Ilze Strumfa, Andrejs Vanags, Arturs Kalva, Dainis Balodis, Boriss Strumfs, Ilze Fridrihsone, Arnis Abolins and Janis

**Biopsy and Evaluation of Systemic Inflammatory Reaction 47** Ilze Strumfa, Dzeina Mezale, Boriss Strumfs, Andrejs Vanags, Arturs Kalva, Dainis Balodis, Ilze Fridrihsone, Arnis Abolins and Janis

Chapter 2 **Diagnostic Algorithm of Hepatocellular Carcinoma: Classics and Innovations in Radiology and Pathology 17**

Chapter 3 **Innovative Blood Tests for Hepatocellular Carcinoma: Liquid**

Chapter 4 **Cellular Senescence and Their Role in Liver Metabolism in**

Brunengraber and Juan Sanabria

**Health and Disease: Overview and Future Directions 69** Matthew Schade, Jacqueline A Sanabria, Milad Modarresi, Bryan Gillon, Zach Hunter, Jacqueline Fannin, Amrita Mallick, Henri

**Hepatocellular Carcinoma 3**

**Section 2 Diagnosis of Hepatocellular Carcinoma 15**

Nicu Dan Florescu

Gardovskis

Gardovskis

**Section 1 Introduction 1**
