**Cellular Senescence and Their Role in Liver Metabolism in Health and Disease: Overview and Future Directions Cellular Senescence and Their Role in Liver Metabolism in Health and Disease: Overview and Future Directions**

DOI: 10.5772/intechopen.71659

Matthew Schade, Jacqueline A Sanabria, Milad Modarresi, Bryan Gillon, Zach Hunter, Jacqueline Fannin, Amrita Mallick, Henri Brunengraber and Juan Sanabria Matthew Schade, Jacqueline A Sanabria, Milad Modarresi, Bryan Gillon, Zach Hunter, Jacqueline Fannin, Amrita Mallick, Henri Brunengraber and Juan Sanabria Additional information is available at the end of the chapter

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.71659

#### **Abstract**

Chronic liver disease has globally risen mainly due to a prevalent hepatitis C virus (HCV) infection rate and an epidemic of obesity. It is estimated by the year 2030, 2.2 billion people around the world will be overweight and 1.1 billion people will be obese. Diabetes and obesity are the main risk factors for the development of the metabolic syndrome and in the liver of non-alcoholic fatty liver disease (NAFLD) which could progress to non-alcoholic fatty steatohepatitis (NASH) related cirrhosis and liver malignancy. At present there is not effective therapy for NASH besides loss of weight and exercise. Furthermore, optimal management of HCC with curative intent includes resection or liver transplantation. Nevertheless, these therapies are limited because the degree of liver dysfunction or the medical conditions at the time of diagnosis and the scarcity of available liver grafts. The role of cellular lipid management and metabolism in human health and disease is taking a center stage. The present overview articulates the current pathophysiology of fatty liver disease under the aging processes, potential biological markers of liver disease diagnosis and progression and future therapies.

**Keywords:** review, senescence, cell aging, mitochondrial function, cancer, obesity, NASH, ROS, lipids, metabolism
