**Meet the editors**

Dr. Cristiana Filip is an Associated Professor at the Department of Biochemistry, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania, since 2008. She became a PhD in Chemistry in 2001 with the thesis entitled "Analytical methods for assessing the bioavailability of some drugs bound to a polymer support" at the Faculty of Chemistry, "Alex-

andru Ioan Cuza" University, Iasi, Romania. She is a senior chemist since 2010, in the Public Health Network, in the field of Medical Biochemistry. Her scientific activity for the last 10 years consists of 4 books (national/ international) and 8 papers (international). She participates as a team member in seven research grants (national/international). She has experience in pharmacokinetic, clinical laboratory of biochemistry, reactive species, and homocysteine metabolism. Her fields of research are reactive species, homocysteine metabolism, and endothelial dysfunction in cardiovascular diseases.

Elena Albu is an Associate Professor of Pharmacology at the Faculty of Medicine "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania, since 2008. She became a PhD in Pharmacology by accomplishing in 2002 the thesis entitled "Pharmacology research of mastocyte and mast cell release substances." She had obtained the clinical specializations in hematology, inter-

nal medicine, and clinical pharmacology. Currently, she practices clinical hematology. Her scientific activity for the last 10 years consists of 8 books (national/international) and 16 papers (international). She participates as a team member in three research grants (national/international). Her scientific interests are in the field of clinical and preclinical research in pain, oxidative stress, hemato-oncology, and cardiovascular pathology.

Contents

**Preface VII**

Filip Cristiana

Ovidiu Alexa

**and Inflammation 69**

Chapter 1 **Introductory Chapter: The Biology of Reactive Species 3**

Chapter 3 **Role of Antioxidant Phytochemicals in Prevention, Formation**

Chapter 5 **Reactive Oxygen Species in Skin Repair, Regeneration, Aging,**

Zhou, Hiroko Isoda, Nobuhiro Ohkohchi and Yu-Mei Li

Chapter 7 **Reactive Oxygen Species at High Altitude (Hypobaric Hypoxia)**

Teppei Takeshima, Shinnosuke Kuroda and Yasushi Yumura

Abdurrahim Kocyigit, Eray Metin Guler and Murat Dikilitas

Roma Patel, Lindsey Rinker, Joanna Peng and William M. Chilian

Nina Filip, Elena Cojocaru, Alexandru Filip, Bogdan Veliceasa and

Hui Xu, Yun-Wen Zheng, Qi Liu, Li-Ping Liu, Feng-Lin Luo, Hu-Chen

Chapter 2 **Reactive Oxygen Species: The Good and the Bad 7**

**and Treatment of Cancer 21**

**Section 2 Reactive Species Involvement in Pathology 47**

Chapter 4 **Reactive Oxygen Species and Bone Fragility 49**

Chapter 6 **Reactive Oxygen Species and Sperm Cells 89**

**on the Cardiovascular System 109** Patricia Siques, Julio Brito and Eduardo Pena

**Section 1 Main Concepts 1**
