**4. Conclusion**

In this way, it is clear that both FOL and the tomato plant are in a long competition of defensive mechanisms to ensure their survival when the plant-pathogen interaction occurs.

FOL genomic analyzes have revealed the evolutionary characteristics of genes associated with FOL adaptation to their hosts, getting to understand the specificity for these. Molecular biology studies have evidenced the genes that are expressed in FOL interactions with their hosts at different stages of infection. However, a greater level of understanding with regard to the interaction mechanisms is needed. Future efforts will be needed to investigate the role of effector proteins in FOL-host interactions.

A study of elicitor molecules of natural or synthetic origin that are recognized as PAMPs and can trigger a nonspecific defense response is necessary. The obtained knowledge will further improve tolerance to vascular wilt of tomato plants by FOL infection.
